Contents of limonoids and limonin 17-.beta.-D-glucopyranoside in fruit tissue of Valencia orange during fruit growth and maturation

Fong, Chi H.; Hasegawa, Shin; Coggins, Charles W.; Atkin, D. R.; Miyazaki, Masaki

doi:10.1021/jf00019a019

Cited by 46 publications

(48 citation statements)

References 5 publications

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“…LGT is limited only to the seed and mature fruits of citrus (27,28). A similar LGT expression in leaves (150 DAF) has been observed in Satsuma mandarin, and in Kinnow mandarin (Fig.…”

supporting

confidence: 77%

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Cloning and Characterization of Limonoid Glucosyltransferase from Kinnow mandarin (Citrus reticulata Blanco)

Arora¹,

Mohanpuria²,

Sidhu³

et al. 2017

Food Technol. Biotechnol.

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“…LGT is limited only to the seed and mature fruits of citrus (27,28). A similar LGT expression in leaves (150 DAF) has been observed in Satsuma mandarin, and in Kinnow mandarin (Fig.…”

supporting

confidence: 77%

“…This means that the expression pattern of CrLGT in leaves is not related to the bitterness level of fruit juice as observed earlier also (18). Further, there is no any report of transport of LG from leaf to fruit and LG once synthesized in the leaf cannot be translocated to another part (27,28).…”

mentioning

confidence: 68%

Cloning and Characterization of Limonoid Glucosyltransferase from Kinnow mandarin (Citrus reticulata Blanco)

Arora¹,

Mohanpuria²,

Sidhu³

et al. 2017

Food Technol. Biotechnol.

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“…Lastly, a method has been reported for the identification of limonoid A ring lactones in citrus samples. In fact, since only indirect chemical and biochemical techniques [157][158][159] or MS detection were available, Breksa III et al finally developed a rapid and reliable LC-ESI-MS method for the direct quantification of limonoate A Rring lactone (LARL, 47, Figure 15) and nomilinoate A ring lactone (NARL, 48, Figure 15) in a wide variety of citrus juices. These limonoid A-ring lactones were isolated by solid-phase extraction from juice samples and analyzed by negative ion LC-ESI-MS while their concentrations were established by fluorescence spectroscopy [160].…”

Section: Limonoid Aglyconesmentioning

confidence: 99%

The Chemistry and Pharmacology of Citrus Limonoids

et al. 2016

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Citrus limonoids (CLs) are a group of highly oxygenated terpenoid secondary metabolites found mostly in the seeds, fruits and peel tissues of citrus fruits such as lemons, limes, oranges, pumellos, grapefruits, bergamots, and mandarins. Represented by limonin, the aglycones and glycosides of CLs have shown to display numerous pharmacological activities including anticancer, antimicrobial, antioxidant, antidiabetic and insecticidal among others. In this review, the chemistry and pharmacology of CLs are systematically scrutinised through the use of medicinal chemistry tools and structure-activity relationship approach. Synthetic derivatives and other structurally-related limonoids from other sources are include in the analysis. With the focus on literature in the past decade, the chemical classification of CLs, their physico-chemical properties as drugs, their biosynthesis and enzymatic modifications, possible ways of enhancing their biological activities through structural modifications, their ligand efficiency metrics and systematic graphical radar plot analysis to assess their developability as drugs are among those discussed in detail.

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“…In juices prepared from mature fruits, limonoid glucosides are the most abundant limonoids and range in concentrations from 150 to 300 ppm [3,4]. Because of their abundance and relevance to citrus quality, capillary electrophoresis (CE) [5,6], high-pressure liquid chromatography (HPLC) [4,7,8], liquid chromatography coupled to mass spectrometry (LC-MS) [9][10][11][12], and thin layer chromatography (TLC) [4] methods have been developed to detect, identify and quantify these compounds. Each of these methods has its own inherent advantages and disadvantages.…”

Section: Introductionmentioning

confidence: 99%

Determination of Citrus Limonoid Glucosides by High Performance Liquid Chromatography Coupled to Post-Column Reaction with Ehrlich’s Reagent

2015

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Abstract:A method for the identification and quantification of citrus limonoid glucosides in juices, based upon high performance liquid chromatography (HPLC) separation coupled to post-column reaction with Ehrlich's reagent, has been developed. This method utilizes a phenyl stationary phase and an isocratic mobile phase. Limit of detection for the method was determined to be 50 ng of limonin glucoside. Limonin glucoside and the other limonoid glucosides tested responded equivalently to the post-column reaction with Ehrlich's reagent suggesting that limonin glucoside may be used as a surrogate for the quantification of other limonoid glucosides, including nomilin, deacetyl nomilin, nomilinic acid, deacetyl nomilinic acid, and obacunone glucosides. For most juice samples, no sample treatment is required to determine limonin glucoside content. Concentration by solid phase extraction is recommended for juices with low levels of limonin glucoside and to facilitate the detection and quantification of other limonoid glucosides present at low concentrations. With the exception of blood oranges, the method was successfully applied to the analysis of juices from a variety of citrus varieties.

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Contents of limonoids and limonin 17-.beta.-D-glucopyranoside in fruit tissue of Valencia orange during fruit growth and maturation

Cited by 46 publications

References 5 publications

Cloning and Characterization of Limonoid Glucosyltransferase from Kinnow mandarin (Citrus reticulata Blanco)

Cloning and Characterization of Limonoid Glucosyltransferase from Kinnow mandarin (Citrus reticulata Blanco)

The Chemistry and Pharmacology of Citrus Limonoids

Determination of Citrus Limonoid Glucosides by High Performance Liquid Chromatography Coupled to Post-Column Reaction with Ehrlich’s Reagent

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