Context and Considerations for Use of Two Japanese Real-World Databases in Japan: Medical Data Vision and Japanese Medical Data Center

Laurent, Thomas; Simeone, Jason C; Kuwatsuru, Ryohei; Hirano, Takahiro; Graham, Sophie; Wakabayashi, Ryozo; Phillips, Bob; Isomura, Tatsuya

doi:10.1007/s40801-022-00296-5

Cited by 58 publications

(48 citation statements)

References 35 publications

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“…After screening the titles and abstracts, 632 studies (NDB, 40 studies; JMDC, 185 studies; MDV, 147 studies; and DPC, 260 studies) were included in this review. A total of 28 studies were added from a previous review of the NDB [ 7 ] and seven from a manual search. Of these, 14 studies were counted as duplicates because they used both the JMDC and MDV.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, it is necessary to understand the characteristics of each database to select the most appropriate database for each research study. The characteristics of each database and aspects to consider when conducting research have already been reported [ 3 , 7 ], but it is not clear whether the research conducted in each database corresponds to the features already pointed out. The only study that has examined the types of studies conducted in the Japanese administrative claims databases was for the NDB [ 8 ], and there have been no studies that have compared the types and designs of studies conducted in each database.…”

Section: Introductionmentioning

confidence: 99%

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A Review of Research Studies Using Data from the Administrative Claims Databases in Japan

Fujinaga

Fukuoka

2022

Drugs - Real World Outcomes

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Background In Japan, several research studies have used administrative claims databases. However, no study has compared the studies conducted in each database. Objective We assessed the type, design, and research area of each research study using the administrative databases in Japan to illustrate the suitability of the database used for the types of research studies. Methods We reviewed studies from four administrative claims databases (the Japanese National Database of Health Insurance Claims and Specific Health Checkups [NDB]; the DPC Study Group database [DPC]; Japan Medical Data Center [JMDC]; and Medical Data Vision [MDV]). The PubMed database was searched from January 2015 to October 2020. We assessed the type, design, and research area of the abstract or full text of each research study. Results Overall, 643 studies were included. The number of studies increased from 59 in 2015 to 171 in 2020. Descriptive studies accounted for 62.7% (42 studies) of the studies from the NDB, while the treatment effectiveness studies accounted for 81.7% (211 studies) of the studies from the DPC database and were the most common in the JMDC and MDV. Cohort studies accounted for only 17.9% of the studies on NDB but 45.5% on DPC. The most common research area was medicine, general, and internal medicine (53 studies, 8.4%). Conclusions The type and design of the studies conducted differed in each database and were influenced by the characteristics of the database used. In the future, it may be necessary to integrate various real-world data databases to increase their comprehensiveness. Supplementary Information The online version contains supplementary material available at 10.1007/s40801-022-00331-5.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Review of Research Studies Using Data from the Administrative Claims Databases in Japan

Fujinaga

Fukuoka

2022

Drugs - Real World Outcomes

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“…The MDV database provides a large representative sample of anonymized Japanese patient data, medical costs, and laboratory results. 7 Additionally, information regarding clinical evaluation of AHP and its types is limited in the literature. This study provides a clinical description of patients who are experiencing several types of porphyria across multiple medical specialties and/or departments, which may assist physicians in recognizing these cases earlier in the disease progression.…”

Section: Discussionmentioning

confidence: 99%

Clinical features of Japanese patients with acute hepatic porphyria

Horie

Yasuoka²,

Adachi

2022

JIMD Reports

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Acute hepatic porphyria (AHP) is a family of rare genetic diseases of heme biosynthesis characterized by severe neurovisceral attacks. The clinical characteristics of patients with AHP as well as the prevalence of AHP in Japan are not well understood. The objectives of this study were to describe clinical characteristics of AHP at time of diagnosis in Japanese patients and to estimate the prevalence of AHP. Patients with porphyria were selected from Japan's Medical Data Vision health care claims database between April 2008 and June 2020. Patient characteristics before and at time of AHP diagnosis were evaluated. Prevalence per 100 000 was estimated during the study period. A total of 391 cases of AHP were included. At time of AHP diagnosis, mean age was 44 years, and the most common type was acute intermittent porphyria. Median time to diagnosis was 3 months, but some patients remained undiagnosed for several years. The most common complications included metabolic disorders (54%) and diabetes mellitus (39%). In addition, the well‐known complications of AHP, including hypertension (22%) and malignant neoplasms of digestive organs (22%), were observed. About 10% of patients received medications that may have aggravated porphyria attacks. The estimated prevalence of AHP in Japan during the study period was 1.18 cases per 100 000 population. At time of diagnosis, many patients with AHP in Japan are already experiencing a high burden of disease‐related complications. Raising AHP awareness may aid physicians in providing an earlier diagnosis and reducing lifetime disease burden.

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“…We used the nationwide health insurance claims database obtained from the medical database vendor JMDC Co., Ltd (Tokyo, Japan) 24 . This database collects anonymized inpatient, outpatient, and dispensing claims data from various health insurance associations and has accumulated over 10 million people since 2005 (approximately 10% of the Japanese population) 25 . As this database is sourced from health insurance associations for company employees and their families, it is representative of the relatively young generation, which is advantageous for maternal health care research 26 , 27 .…”

Section: Methodsmentioning

confidence: 99%

Trend in neuraxial morphine use and postoperative analgesia after cesarean delivery in Japan from 2005 to 2020

Yonekura

Mazda

Noguchi

et al. 2022

Sci Rep

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The increasing rate of cesarean deliveries warrants obstetric anesthesiologists to deliver high-quality post-cesarean delivery analgesia. The aim of this study was to evaluate the temporal trends in the use of neuraxial morphine for cesarean deliveries and to describe the current postoperative analgesia practices. A retrospective cohort study using nationwide health insurance claims databases was conducted from 2005 to 2020 in Japan. Pregnant women who had undergone cesarean deliveries were included. The annual rate of neuraxial morphine use was extracted and analyzed. Additionally, we explored the patient- and facility-level factors associated with neuraxial morphine use through a multilevel logistic regression analysis. The cohort included 65,208 cesarean delivery cases from 2275 institutions. The prevalence of neuraxial morphine use was 16.0% (95% confidence interval [CI], 15.8–16.3) in the overall cohort. Intrathecal morphine was used in 20.6% (95% CI, 20.2–21.0) of spinal anesthesia cases. The trend in neuraxial morphine use steadily increased from 2005 to 2020. The significant predictors of neuraxial morphine use included spinal anesthesia, recent surgery, large medical facilities, and academic hospitals. Variations in the utilization of postoperative analgesia were observed. Our study described the current trend of neuraxial morphine use and the variation in postoperative analgesia practice in Japan.

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Context and Considerations for Use of Two Japanese Real-World Databases in Japan: Medical Data Vision and Japanese Medical Data Center

Cited by 58 publications

References 35 publications

A Review of Research Studies Using Data from the Administrative Claims Databases in Japan

A Review of Research Studies Using Data from the Administrative Claims Databases in Japan

Clinical features of Japanese patients with acute hepatic porphyria

Trend in neuraxial morphine use and postoperative analgesia after cesarean delivery in Japan from 2005 to 2020

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