The goal of the current study was to experimentally manipulate perceived overqualification (POQ) among a sample of therapists and assess this manipulation’s effect on task meaningfulness, positive affect, and negative affect. To conduct the experiment, we had participants read a clinical case vignette and then randomly assigned them to answer questions using their specialized clinical skills (control group) or using simple recall and transcription (perceived overqualification group). The POQ group reported significantly greater perceived overqualification and significantly less task meaningfulness than the control group. Perceived overqualification also mediated the relation between the experimental condition and task meaningfulness. The groups did not differ on positive or negative affect. Results support previous research and theory suggesting that perceived overqualification can have deleterious effects on job attitudes, which has implications for organizational and individual interventions.