Context-dependent genomic locus effects on antibody production in recombinant Chinese hamster ovary cells generated through random integration

Woo, Hyun Jee; Kim, Jaehoon; Kim, Seul Mi; Kim, Dongwoo; Moon, Jae Yun; Park, Daechan; Lee, Jae Seong

doi:10.1016/j.csbj.2024.04.023

Computational and Structural Biotechnology Journal

2024

DOI: 10.1016/j.csbj.2024.04.023

|View full text |Cite

Context-dependent genomic locus effects on antibody production in recombinant Chinese hamster ovary cells generated through random integration

Hyun Jee Woo,

Jaehoon Kim,

Seul Mi Kim

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Effect of CHO cell line constructed with CMAH gene-directed integration on the recombinant protein expression

Cao,

Yuan,

Bai

et al. 2024

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Effect of CHO cell line constructed with CMAH gene-directed integration on the recombinant protein expression

Cao,

Yuan,

Bai

et al. 2024

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Advancements in mammalian display technology for therapeutic antibody development and beyond: current landscape, challenges, and future prospects

Slavny,

Hegde,

Doerner

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

The evolving development landscape of biotherapeutics and their growing complexity from simple antibodies into bi- and multi-specific molecules necessitates sophisticated discovery and engineering platforms. This review focuses on mammalian display technology as a potential solution to the pressing challenges in biotherapeutic development. We provide a comparative analysis with established methodologies, highlighting key aspects of mammalian display technology, including genetic engineering, construction of display libraries, and its pivotal role in hit selection and/or developability engineering. The review delves into the mechanisms underpinning developability-driven selection via mammalian display and their broader implications. Applications beyond antibody discovery are also explored, alongside advancements towards function-first screening technologies, precision genome engineering and AI/ML-enhanced libraries, situating them in the context of mammalian display. Overall, the review provides a comprehensive overview of the current mammalian display technology landscape, underscores the expansive potential of the technology for biotherapeutic development, addresses the critical challenges for the full realisation of this potential, and examines advances in related disciplines that might impact the future application of mammalian display technologies.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Context-dependent genomic locus effects on antibody production in recombinant Chinese hamster ovary cells generated through random integration

Cited by 2 publications

References 44 publications

Effect of CHO cell line constructed with CMAH gene-directed integration on the recombinant protein expression

Effect of CHO cell line constructed with CMAH gene-directed integration on the recombinant protein expression

Advancements in mammalian display technology for therapeutic antibody development and beyond: current landscape, challenges, and future prospects

Contact Info

Product

Resources

About