2009
DOI: 10.1016/j.mod.2009.04.004
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Context-specific requirements of functional domains of the Spectraplakin Short stop in vivo

Abstract: Spectraplakins are large multifunctional cytoskeletal interacting molecules implicated in various processes, including gastrulation, wound healing, skin blistering and neuronal degeneration. It has been speculated that the various functional domains and regions found in Spectraplakins are used in context-specific manners, a model which would provide a crucial explanation for the multifunctional nature of Spectraplakins. Here we tested this possibility by studying domain requirements of the Drosophila Spectrapl… Show more

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Cited by 43 publications
(67 citation statements)
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“…Two calponin homology domains (CH1 and CH2) form a classical actin-binding domain (ABD) essential for neuronal morphogenesis (Alves-Silva et al, 2012;Jefferson, Leung, & Liem, 2004;Kodama, Lechler, & Fuchs, 2004;Lee & Kolodziej, 2002b;Leung, Sun, Zheng, Knowles, & Liem, 1999). The plakinhomology domain (six to nine spectrin-like repeats and an SH3 domain embedded in the 5th repeat) links to transmembrane collagens and β4 integrin in BPAG1e (Aumailley, Has, Tunggal, & Bruckner-Tuderman, 2006;Koster, Geerts, Favre, Borradori, & Sonnenberg, 2003) and mediates compartmentalization of transmembrane proteins in fly neurons (Bottenberg et al, 2009). The spectrin/dystrophin repeat rod domain likely acts as spacer or in dimerization (Bottenberg et al, 2009;Leung et al, 1999;Machnicka et al, 2014;R€ oper, Gregory, & Brown, 2002).…”
Section: P0010mentioning
confidence: 99%
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“…Two calponin homology domains (CH1 and CH2) form a classical actin-binding domain (ABD) essential for neuronal morphogenesis (Alves-Silva et al, 2012;Jefferson, Leung, & Liem, 2004;Kodama, Lechler, & Fuchs, 2004;Lee & Kolodziej, 2002b;Leung, Sun, Zheng, Knowles, & Liem, 1999). The plakinhomology domain (six to nine spectrin-like repeats and an SH3 domain embedded in the 5th repeat) links to transmembrane collagens and β4 integrin in BPAG1e (Aumailley, Has, Tunggal, & Bruckner-Tuderman, 2006;Koster, Geerts, Favre, Borradori, & Sonnenberg, 2003) and mediates compartmentalization of transmembrane proteins in fly neurons (Bottenberg et al, 2009). The spectrin/dystrophin repeat rod domain likely acts as spacer or in dimerization (Bottenberg et al, 2009;Leung et al, 1999;Machnicka et al, 2014;R€ oper, Gregory, & Brown, 2002).…”
Section: P0010mentioning
confidence: 99%
“…The plakinhomology domain (six to nine spectrin-like repeats and an SH3 domain embedded in the 5th repeat) links to transmembrane collagens and β4 integrin in BPAG1e (Aumailley, Has, Tunggal, & Bruckner-Tuderman, 2006;Koster, Geerts, Favre, Borradori, & Sonnenberg, 2003) and mediates compartmentalization of transmembrane proteins in fly neurons (Bottenberg et al, 2009). The spectrin/dystrophin repeat rod domain likely acts as spacer or in dimerization (Bottenberg et al, 2009;Leung et al, 1999;Machnicka et al, 2014;R€ oper, Gregory, & Brown, 2002). Plectin-repeat domains (PRD) typically bind intermediate filaments (Aumailley et al, 2006;Jefferson et al, 2004).…”
Section: P0010mentioning
confidence: 99%
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