2012
DOI: 10.1073/pnas.1114415109
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Contextual encoding by ensembles of medial prefrontal cortex neurons

Abstract: Contextual representations serve to guide many aspects of behavior and influence the way stimuli or actions are encoded and interpreted. The medial prefrontal cortex (mPFC), including the anterior cingulate subregion, has been implicated in contextual encoding, yet the nature of contextual representations formed by the mPFC is unclear. Using multiple single-unit tetrode recordings in rats, we found that different activity patterns emerged in mPFC ensembles when animals moved between different environmental con… Show more

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Cited by 211 publications
(242 citation statements)
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“…Although our recordings do not provide causal evidence, our data are consistent with previous work indicating that a major aspect of prefrontal signaling is integrating contextual information to produce goal-directed responses (2,3,22). This concept aligns with studies indicating that an important role of the PFC is to generate contextappropriate behavior (23).…”
Section: Discussionsupporting
confidence: 81%
“…Although our recordings do not provide causal evidence, our data are consistent with previous work indicating that a major aspect of prefrontal signaling is integrating contextual information to produce goal-directed responses (2,3,22). This concept aligns with studies indicating that an important role of the PFC is to generate contextappropriate behavior (23).…”
Section: Discussionsupporting
confidence: 81%
“…Previous studies have revealed mPFC neurons that respond during periods of movement (Euston and McNaughton, 2006;Jung et al, 1998), operant responses like lever presses or nose pokes (Chang et al, 2002;Horst and Laubach, 2012;Hyman et al, 2012;Totah et al, 2013), and preparatory activity prior to the start of learned action sequences (Chang et al, 2002;Jung et al, 1998;Totah et al, 2009Totah et al, , 2013. Here normalised population analyses revealed distinct temporal patterns of excitation coincident with all periods of movement without directional specificity (movement 1), movements towards sample and choice responses with evidence of directional specificity (movement 2), during all lever press responses (lever press excitation), specifically during start and delay lever presses (base lever press), and prior to start and delay responses that began the sample and choice phases of dDNMTP (preparatory).…”
Section: Event-related Responsesmentioning
confidence: 99%
“…9), but because trajectory directions are variable in this task, trajectory-dependent activity is likely to be cancelled out in time-averaged rate maps. The colour-reversal task should be sufficiently sensitive to detect influences of discrete stimuli, considering that mPFC cells do respond to such changes under other conditions 47 .…”
Section: Legends For Extendedmentioning
confidence: 99%