Nowadays, urban sprawl phenomenon have been seen in many of cities in the developing and developed countries. Urban sprawl is considered as a particular kind of urban growth which comes up with a lot of negative effects. Thus, monitoring, analyzing and modeling of this phenomenon seem to be unavoidable. This paper assess urban sprawl in Tehran Metropolis as the capital of Iran and models urban sprawl in this mega city utilizing artificial neural networks and adaptive neuro-based fuzzy inference system methods with remote sensing data and geospatial information systems spatial analyses and modeling capabilities to simulate Tehran urban growth. The results confirm that this city has experienced sprawl and sprawl has an increasing rate. Three Landsat imageries from TM and ETM? sensors taken in 1988, 1999 and 2010 and seven predictor variables include distance to road, distance to green space, slope, elevation, distance to fault, distance to developed area and number of urban cells in 3 by 3 neighborhoods have been used for urban sprawl assessment and modeling. Relative operating characteristics (ROC) and sensitivity analyses have been used to evaluate simulation results. In this research, two evaluation steps have been implemented using ROC and on the both of them, ANFIS presented the best performance vs two different proposed ANN structures.