Contextual renewal of cocaine seeking in rats and its attenuation by the conditioned effects of an alternative reinforcer

Kearns, David N.; Weiss, Stanley J.

doi:10.1016/j.drugalcdep.2007.03.006

Cited by 54 publications

(60 citation statements)

References 55 publications

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“…Finally, Kearns & Weiss (2007) assessed whether cocaine-associated contexts reinstate (renew) drug seeking by serving as discriminative drug cues. They reported that exposure to the cocaine context selectively reinstates the ability of a discriminative tone cue to control nose-poke responding after extinction of the tone's discriminated response in a non-drug context.…”

Section: Pavlovian-instrumental Transfer (Pit ) Refers To the Abilitmentioning

confidence: 99%

Context-induced relapse to drug seeking: a review

Crombag

Bossert

Koya

et al. 2008

Phil. Trans. R. Soc. B

454

382

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In humans, exposure to environmental contexts previously associated with drug intake often provokes relapse to drug use, but the mechanisms mediating this relapse are unknown. Based on early studies by Bouton & Bolles on context-induced 'renewal' of learned behaviours, we developed a procedure to study context-induced relapse to drug seeking. In this procedure, rats are first trained to self-administer drug in one context. Next, drug-reinforced lever responding is extinguished in a different (non-drug) context. Subsequently, context-induced reinstatement of drug seeking is assessed by re-exposing rats to the drug-associated context. Using variations of this procedure, we and others reported reliable context-induced reinstatement in rats with a history of heroin, cocaine, heroin-cocaine combination, alcohol and nicotine self-administration. Here, we first discuss potential psychological mechanisms of context-induced reinstatement, including excitatory and inhibitory Pavlovian conditioning, and occasion setting. We then summarize results from pharmacological and neuroanatomical studies on the role of several neurotransmitter systems (dopamine, glutamate, serotonin and opioids) and brain areas (ventral tegmental area, accumbens shell, dorsal striatum, basolateral amygdala, prefrontal cortex, dorsal hippocampus and lateral hypothalamus) in context-induced reinstatement. We conclude by discussing the clinical implications of rat studies on context-induced reinstatement of drug seeking.

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Section: Pavlovian-instrumental Transfer (Pit ) Refers To the Abilitmentioning

confidence: 99%

Context-induced relapse to drug seeking: a review

Crombag

Bossert

Koya

et al. 2008

Phil. Trans. R. Soc. B

454

382

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“…The associative strength of X during conditioning in Group Blocking is correctly predicted to be lower than in Group Control. The renewal paradigm has been extensively investigated in drug addiction studies, including cocaine [20], heroine [21], nicotine [22], and alcohol [23], as well as in anxiety disorders [24] and post-traumatic stress disorders [25].…”

Section: Context Blockingmentioning

confidence: 99%

An extension of the Rescorla and Wagner Simulator for context conditioning

Mondragón¹,

Alonso

Fernández

et al. 2013

Computer Methods and Programs in Biomedicine

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“…Research with animals has reliably demonstrated ABA renewal with a variety of drugs including cocaine [13,36], heroin [37], nicotine [38], and alcohol [39].…”

Section: Renewal Effectmentioning

confidence: 99%

“…From this perspective, responding renews not because of an uncovering of the original association (Pavlovian) but rather due to an increased tendency to respond while in the presence of stimuli that signal drug availability for responding. However, [36] manipulated their procedure to assess both Pavlovian and operant interpretations and concluded that the context served as a Pavlovian occasion setter and not as an operant discriminative stimulus. Furthermore, when alternative forms of reinforcement were available, the extent to which contextual renewal occurred was reduced [36].…”

Section: Renewal Effectmentioning

confidence: 99%

“…However, [36] manipulated their procedure to assess both Pavlovian and operant interpretations and concluded that the context served as a Pavlovian occasion setter and not as an operant discriminative stimulus. Furthermore, when alternative forms of reinforcement were available, the extent to which contextual renewal occurred was reduced [36].…”

Section: Renewal Effectmentioning

confidence: 99%

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Extinction Learning as a Model of Drug Treatment and Relapse: A Behavioral Overview

Widholm¹

2013

TOADDJ

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Extinction is the process by which a previously established stimulus relationship is broken by the removal of reinforcers and/or biologically relevant stimuli, causing a reduction in responding. Given the importance of this phenomenon in terms of understanding not only learning and behavior, but also of enhancing our understanding of drug addiction and treatment, there is renewed attention being given to the study of extinction in the behavioral, neuroscientific, and therapeutic disciplines. The purpose of the current review is to provide an overview of the basic Pavlovian extinction paradigm and its relevance for treating drug addiction and discuss the typical "threats to extinction" as they model the tendency for drug relapse.

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Contextual renewal of cocaine seeking in rats and its attenuation by the conditioned effects of an alternative reinforcer

Cited by 54 publications

References 55 publications

Context-induced relapse to drug seeking: a review

Context-induced relapse to drug seeking: a review

An extension of the Rescorla and Wagner Simulator for context conditioning

Extinction Learning as a Model of Drug Treatment and Relapse: A Behavioral Overview

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