Experiments aimed at testing some hypothesis about the nature of Single Bubble Sonoluminescence are discussed. A possibility to search for micro-traces of thermonuclear neutrons is analyzed, with the aid of original low-background neutron counter operating under conditions of the deep shielding from Cosmic and other sources of background. Besides, some signatures of QED-contribution to the light emission in SBSL are under the consideration, as well as new approaches to probe a temperature inside the bubble. An applied-physics portion of the program is presented also, in which an attention is being paid to single-and a few-pulse light sources on the basis of SBSL.