Contingency awareness, aging, and the parietal lobe

Cheng, Dominic T.; Katzenelson, Alyssa M.; Faulkner, Monica L.; Disterhoft, John F.; Power, John M.; Desmond, John E.

doi:10.1016/j.neurobiolaging.2020.02.024

Cited by 4 publications

(4 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…9). In a study on emergency awareness, compared with young people, the elderly showed excessive activation of the parietal lobe, which proved that the age-related destruction of the parietal lobe was enough to weaken consciousness [52]. And as mentioned earlier, the initial manifestation of Alzheimer's disease may appear in the right parietal lobe.…”

Section: The Influence Of the Bc Of Cp1 Nodes On The Wmmentioning

confidence: 78%

The Effect of Multiple Factors on Working Memory Capacities: Aging, Task Difficulty, and Training

Huang

Pei

et al. 2023

IEEE Trans. Biomed. Eng.

View full text Add to dashboard Cite

Working memory (WM) is a memory system with a limited capacity that can process and store information temporarily in the performing of cognitive tasks. Despite WM is known to be influenced by age, the difficulty of tasks and trained or not from behavior studies, little is known about their relationships from the aspect of the brain functional network. Our goal was to explore the factor of aging-related changes of WM with brain functional networks. Methods: In this study, 25 healthy elderly and 23 healthy young volunteers were recruited for electroencephalogram (EEG) recording during the visual WM task with four difficulty levels (1-4 backs). In each back, we repeat the experiment with four sessions, and we add training sections between session one and session two as well as between session two and session three. However, we remove any training section between session three and session four in order to evaluate the impact of forgetting on WM in different age groups. After the experiment, we utilized graph theoretical analysis to characterize the brain functional network in three frequency bands (alpha, beta, and theta). Results: From the well-designed experiment, we found that physiological aging influences brain network connectivity and makes the functional brain network less differentiated. Moreover, there is an inverse relationship between alpha activity and WM load for the elderly group, which is absent in the young group. At the same time, theta band activity will be correlated with behavioral performance for the elderly group with WM training between sessions, which is also absent in the young group. To further study the influence of difficulty of tasks and training on the WM, we distinguish the tasks with quantified topological characteristics, and the classification results manifest that the training is more effective for the young group. Finally, through the establishment of a brain map before and after training, we find that the right parietal lobe plays an important role in the training of WM for the elderly group whereas the beta band plays an important role in WM for both the elderly group and the young group. Conclusion: Taken together, our findings

show abstract

Section: The Influence Of the Bc Of Cp1 Nodes On The Wmmentioning

confidence: 78%

The Effect of Multiple Factors on Working Memory Capacities: Aging, Task Difficulty, and Training

Huang

Pei

et al. 2023

IEEE Trans. Biomed. Eng.

View full text Add to dashboard Cite

show abstract

“…The expression level of Ngb in the parietal lobe (P <0.05) recorded the highest, and the expression results were consistent in both yak and cattle. The parietal lobe is located between the frontal lobe and occipital lobe (The Neuroscientist, 2017;Abhang et al, 2016), and it was involved in a number of complex tasks involving attention, integration of information such as recognition, visuospatial abilities and appreciation of environmental cues and the appropriate connection of sensory input to action (Cheng et al, 2020;Mehler and Reschechtko, 2018;Caspers and Zilles, 2018). Therefore, in order to maintain the steady-state environment in the parietal lobe of yak and cattle, Ngb may play a positive role.…”

Section: Discussionmentioning

confidence: 99%

Comparative study on the distribution and expression of Neuroglobin and Hypoxia-inducible factor-1α in the telencephalon of yak and cattle

Liu

Mawolo

2023

Braz. J. Biol.

View full text Add to dashboard Cite

The telencephalon refers to the most highly developed and anterior part of the forebrain, consisting mainly of the cerebral hemispheres. The study determined Neuroglobin (Ngb) and Hypoxia-inducible factor (HIF-1α) expression in the telencephalon of yak and cattle, and compare the expression and distribution pattern of Ngb and HIF-1α in the two animals. Immunohistochemistry (IHC), quantitative real-time Polymerase Chain Reaction (qRT-PCR), and Western blot (WB) were employed to investigate Ngb and Hif-1α expression in the telencephalon of yak and cattle. mRNA and protein expressions of Ngb and HIF-1α showed positive in different tissues of the yak and cattle telencephalon. Ngb expression in tissues of the yak recorded higher as compare to cattle while HIF-1α expression was found higher in cattle than yak. The HIF-1α expression in some tissues of yak telencephalon was consistent with the cattle. The results documented that HIF-1α may have a direct or indirect synergistic effect on Ngb expression in the yak telencephalon to improve hypoxia adaptation. It is suggested that yak may need more Ngb expression for adaptation, but the expression of HIF-1α seems to be down-regulated during long-term adaptation, and the specific causes of this phenomenon needs to be further verified.

show abstract

“…It is well known that old animals and humans tends to be less aware or conscious (Cheng et al , 2020). The ability to learn, and form new memories are significantly reduced.…”

Section: Disorders Of Consciousness and Brain Injurymentioning

confidence: 99%

Cortical synaptic basis of consciousness

Zhuo

2023

Preprint

View full text Add to dashboard Cite

Consciousness is one of final questions for humans to tackle in neuroscience. Due to the lack of understanding of the basic brain network and mechanisms of functions, our knowledge of consciousness remains at the theoretical level. Recent studies using brain imaging in humans and modern neuroscience techniques in animal studies reveal a basic brain network for consciousness. The projection from the thalamus to different cortical regions form a network of activities to maintain consciousness in human and animals. These feedback and feedforward circuits maintain the consciousness even in certain brain injury conditions. Proteins and ion channels that contribute to these circuit neural activities are targets for drugs and manipulations that affect consciousness, such as anesthetic agents. Synaptic plasticity that trains synapses during learning and information recall, modify circuits and contribute to a high level of consciousness in certain populations.

show abstract

Contingency awareness, aging, and the parietal lobe

Cited by 4 publications

References 66 publications

The Effect of Multiple Factors on Working Memory Capacities: Aging, Task Difficulty, and Training

The Effect of Multiple Factors on Working Memory Capacities: Aging, Task Difficulty, and Training

Comparative study on the distribution and expression of Neuroglobin and Hypoxia-inducible factor-1α in the telencephalon of yak and cattle

Cortical synaptic basis of consciousness

Contact Info

Product

Resources

About