Contingent Negative Variation and Personality in Depression

Abstract

Contingent negative variation (CNV) has been applied in depression with controversial results. A major source for these controversial results could result from the diversity of depressed patients included in the different studies. Supporting this assumption, impulsivity, blunted affect and suicidal behavior significantly influence CNV amplitude. However, no data are available on the possible influences of personality of depressed patients on CNV. Since personality is related to CNV in normal subjects, the aim of the present study was to investigate the relationship between CNV and personality as assessed by the Temperament and Character Inventory (TCI) in 52 depressed patients. A group of 76 healthy volunteers was included in the study. Among depressed patients, the main results of the study shows that CNV amplitude is positively correlated with self-transcendence dimension. In healthy volunteers, results show that CNV amplitude is negatively correlated with novelty seeking and persistence dimensions. The other dimensions are not related to CNV amplitude either in depressed patients or in healthy volunteers. The findings among depressed subjects suggest that lower CNV amplitude may be associated with psychotic traits (high self-transcendence scores), and those observed in healthy subjects are consistent with previous studies and support energetical models of slow potentials. However, the preliminary nature of the present results with respect to the weak statistical significance should be underlined.

Deficit in late-stage contingent negative variation provides evidence for disrupted movement preparation in patients with conversion paresis

“…Reduced CNV amplitudes in psychiatric populations have been previously reported, for example in depressed and neurotic patients (Giedke & Bolz, 1980;Hansenne & Ansseau, 2001;TimsitBerthier et al, 1973) and in individuals with high levels of anxiety or stress (Knott & Irwin, 1973;Low & Swift, 1971;McCallum & Walter, 1968a, 1968b. It is therefore possible that our results were confounded by the presence of comorbid psychiatric disorder, which is common in patients with conversion symptoms (Binzer, Andersen, & Kullgren, 1997;Crimlisk et al, 1998).…”

Effects of Electroacupuncture Combined With Psychological Intervention on Depressive Status and Contingent Negative Variation in Patients With Internet Addiction Disorder: A Randomized Controlled Trial

“…Because the CNV amplitude in the scalp record at the highest of the central band, so the CNV waveform at Cz was used as analysis indicators. Previous studies have found that the CNV amplitude decreases in patients with depression (48,49) and IGD (32). In our study, we found that the CNV amplitude increased in all three groups of IAD patients after treatment, accompanied by a decrease in depression scale scores.…”

“…The higher the total score is, the more serious the degree of Internet addiction is. According to the IAT score, the tested subjects can be classified into normal (0-30), mild (31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49), moderate (50-79), and severe (80-100) types (38). In our study, the subjects included were moderate to severe IAD.…”

Neurophysiological Determinants of Tic Severity in Children with Chronic Motor Tic Disorder

“…This deficiency of resource mobilization and executive control may explain why children with TD and Tourette syndrome are often characterized by high impulsivity and emotionality as well as high comorbidity with both externalizing attention-deficit hyperactivity and internalizing emotional disorders (Banaschewski et al 2003Gaze et al 2006;Roessner et al 2007). Low CNV amplitudes may illustrate a common neurophysiological basis for TD, ADHD and emotional disorders, since patients with both ADHD and depression are characterized by low tCNV and iCNV amplitudes (Banaschewski et al 2008;Benikos and Johnstone 2009;Hansenne and Ansseau 2001). Moreover, diminished resource mobilization and executive control over neuropsychological functions have been demonstrated in both ADHD and depression Schneider et al 1992).…”