Continued demographic shifts in hospitalised patients with COVID-19 from migrant workers to a vulnerable and more elderly local population at risk of severe disease

Ngiam, Jinghao Nicholas; Chhabra, Srishti; Goh, Wilson Wen Bin; Sim, Meng Ying; Chew, Nicholas; Sia, Ching‐Hui; Cross, Gail Brenda; Tambyah, Paul A

doi:10.1016/j.ijid.2022.12.007

Cited by 5 publications

(6 citation statements)

References 23 publications

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“…Only hospitalised patients were examined, while those cared for in community isolation facilities not requiring hospital admission were excluded, because these patients would not have had laboratory tests performed. Some details of this cohort have previously been reported [7 , 8] .…”

Section: Methodsmentioning

confidence: 99%

“…Early in the pandemic in Singapore, the disease mainly affected young and relatively healthy migrant workers living in dormitories, where living conditions amplified spread [28] . Eventually, virus transmission from the younger working-age population entered the more vulnerable and older adults [8] .…”

Section: Limitationsmentioning

confidence: 99%

“…In 2020 and 2021, Singapore's strategy to curb the spread of the disease included active case finding, contact tracing to identify COVID-19 cases, and subsequent isolation [6] . Before large purpose-built facilities were set up to isolate patients with COVID-19, many were housed in tertiary hospitals [7 , 8] . This provided a unique opportunity for clinicians to study the progression from relatively asymptomatic, non-severe COVID-19 to severe critical illness.…”

Section: Introductionmentioning

confidence: 99%

“…This provided a unique opportunity for clinicians to study the progression from relatively asymptomatic, non-severe COVID-19 to severe critical illness. These patients often had baseline laboratory parameters performed upon admission for isolation, including a C-reactive protein (CRP) level obtained within 24 hours of admission [7 , 8] .…”

Section: Introductionmentioning

confidence: 99%

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Inflammatory phenotypes may be more important than age and comorbidities in predicting clinical outcomes in hospitalised patients with COVID-19

et al. 2023

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Section: Methodsmentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Inflammatory phenotypes may be more important than age and comorbidities in predicting clinical outcomes in hospitalised patients with COVID-19

et al. 2023

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“…In Singapore, the coronavirus disease 2019 (COVID‐19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) affected predominantly young and healthy migrant workers in 2020, before causing large outbreaks amongst the more elderly and vulnerable local population in 2021 1 . COVID‐19 vaccine rollout was swift in Singapore, but changes in the circulating strains with their increased infectivity and limited vaccine efficacy led to continued outbreaks of the Omicron variant in 2022 and 2023, as in other parts of the world 2 …”

Section: Parameter Moderate‐to‐severe Illness (Required Supplemental ...mentioning

confidence: 99%

Predictors of disease severity in SARS‐CoV‐2 omicron variant XBB sublineages and variants of interest

Ngiam,

Ng,

Toh

et al. 2023

Journal of Medical Virology

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The Omicron variant has been reported to present with milder disease compared with Delta, although this may be due to immunity from vaccination and prior exposure. Predictors of severity with recent strains have not been well characterized. We retrospectively examined consecutive cases of moderate‐to‐severe COVID‐19 (defined as requiring supplemental oxygenation, intensive care or mortality) admitted to seven tertiary hospitals across Singapore in April 2023. Whole genome sequencing was performed on each isolate to determine the sublineage, while baseline clinical, laboratory data and outcomes were tabulated. We reviewed 182 patients with moderate‐to‐severe illness and 466 controls hospitalized at the same time. Advanced age and presence of chronic kidney disease predicted adverse outcome. Previously reported markers such as radiographic evidence of pneumonia, elevated C‐reactive protein and serum creatinine levels at presentation also correlated with adverse outcomes. There were no observable differences in outcomes with any specific Omicron XBB sublineage. We did not find any specific Omicron XBB sublineage that was associated with worse outcomes. Larger multinational studies would be important to track the clinical evolution of the virus in its current endemic state.

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Venous thromboembolism in an Asian COVID-19 cohort across 3 infection waves—a retrospective observational study

Lee,

Teo,

Lim

et al. 2023

Research and Practice in Thrombosis and Haemostasis

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Continued demographic shifts in hospitalised patients with COVID-19 from migrant workers to a vulnerable and more elderly local population at risk of severe disease

Cited by 5 publications

References 23 publications

Inflammatory phenotypes may be more important than age and comorbidities in predicting clinical outcomes in hospitalised patients with COVID-19

Inflammatory phenotypes may be more important than age and comorbidities in predicting clinical outcomes in hospitalised patients with COVID-19

Predictors of disease severity in SARS‐CoV‐2 omicron variant XBB sublineages and variants of interest

Venous thromboembolism in an Asian COVID-19 cohort across 3 infection waves—a retrospective observational study

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