Continued survival gains in recent years among critically ill myeloma patients

Peigne, Vincent; Rusínová, Kateřina; Karlin, Lionel; Darmon, Michaël; Fermand, Jean‐Paul; Schlemmer, Benoı̂t; Azoulay, Élie

doi:10.1007/s00134-008-1320-4

Cited by 115 publications

(81 citation statements)

References 31 publications

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“…Previous studies of patients with hematological malignancies and sepsis or septic shock showed improved outcomes as a result of earlier treatment of organ failures. 6,31,32 Conceivably, understanding early predictors of invasive mechanical ventilation would improve mortality.…”

Section: Discussionmentioning

confidence: 99%

“…24,29 More recently, outcomes have improved. 6,31,32 In this study, subjects who received early or prophylactic NIV (ie, NIV trial in a subject without any intubation criteria and no other organ failure) were not distinguished from subjects who received curative NIV (ie, NIV trial in a subject with intubation criteria or asso- ciated organ failure). The number of analyzed subjects treated with NIV was limited in this study, so we cannot draw definite conclusions from this set of data.…”

Section: Discussionmentioning

confidence: 99%

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Identifying Cancer Subjects With Acute Respiratory Failure at High Risk for Intubation and Mechanical Ventilation

Lemiale¹,

Lambert

Canet

et al. 2014

Respir Care

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BACKGROUND: We sought to identify risk factors for mechanical ventilation in patients with malignancies and acute respiratory failure (ARF). METHODS:We analyzed data from a previous randomized controlled trial in which nonintubated oncology and hematology subjects with ARF were randomized to early bronchoalveolar lavage or routine care in 16 ICUs in France. Consecutive patients with malignancies were admitted to the ICU for ARF in 2005 and 2006 with no intervention. RESULTS: During the study period, 219 patients were admitted to the ICU for ARF, and 8 patients were not included due to a nonintubation order. Data on the underlying disease, pulmonary involvement, and extrapulmonary organ dysfunctions were recorded at admission in the 211 remaining subjects. Ventilatory support included oxygen only (49 subjects), noninvasive ventilation (NIV) only (81 subjects), NIV followed by invasive mechanical ventilation (49 subjects), and firstline invasive mechanical ventilation (32 subjects). The 81 subjects who required invasive mechanical ventilation were compared with the 130 subjects who remained on oxygen or NIV. Factors associated with invasive mechanical ventilation by multivariate analysis were the oxygen flow required at ICU admission, the number of quadrants involved on chest x-ray, and hemodynamic dysfunction. Mortality rates for subjects who had NIV failure were 65.3% compared with 50% for subjects who were first-line intubated (P ‫؍‬ .34). CONCLUSIONS: In cancer patients with ARF, hypoxemia, extent of pulmonary infiltration on chest x-ray, or hemodynamic dysfunction are risk factors for invasive mechanical ventilation. Mortality was not significantly different between NIV failure and first-line intubation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Identifying Cancer Subjects With Acute Respiratory Failure at High Risk for Intubation and Mechanical Ventilation

Lemiale¹,

Lambert

Canet

et al. 2014

Respir Care

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“…These studies highlighted not only the beneficial impact of advances in critical care and in hematology and oncology, but also the inadequacy of our triage criteria [12]. Furthermore, they have established that a crucial goal is the early management (and even prevention) of organ dysfunction [13,14].…”

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confidence: 99%

Critical care management of lung cancer patients to prolong life without prolonging dying

Soares

Azoulay

2009

Intensive Care Med

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“…Three elements have been perfectly demonstrated. The first is that the prognosis of patients suffering from MM requiring ICU admission improves over the years, probably in relation to the existence of new therapies [7]. The second is that the duration of treatment of 1 month is far too short to presume the recovery or not or to determine the renal function to avoid dialysis.…”

mentioning

confidence: 97%