Continued transmission of Pseudomonas aeruginosa from a wash hand basin tap in a critical care unit

Garvey, Mark I.; Bradley, C.W.; Tracey, Julie; Oppenheim, Beryl

doi:10.1016/j.jhin.2016.05.004

Cited by 42 publications

(19 citation statements)

References 7 publications

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“…Water contaminated with pathogens has been associated with colonization and infection with outbreaks attributed to the water supply 4 . ‐ 10 A source of sterile water (eg, sterile water for irrigation) is considered best practice for the immunocompromised patient and for reconstituting powdered enteral formula. The same water could be used for preparing (diluting, reconstituting, compounding) medication because it is an example of purified water (ie, contaminant free), even though the sterility is not required.…”

Section: Appendix 1 Watermentioning

confidence: 99%

ASPEN Safe Practices for Enteral Nutrition Therapy

Boullata

Carrera²,

Harvey

et al. 2016

J Parenter Enteral Nutr

352

531

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Enteral nutrition (EN) is a valuable clinical intervention for patients of all ages in a variety of care settings. Along with its many outcome benefits come the potential for adverse effects. These safety issues are the result of clinical complications and of process-related errors. The latter can occur at any step from patient assessment, prescribing, and order review, to product selection, labeling, and administration. To maximize the benefits of EN while minimizing adverse events requires that a systematic approach of care be in place. This includes open communication, standardization, and incorporation of best practices into the EN process. This document provides recommendations based on the available evidence and expert consensus for safe practices, across each step of the process, for all those involved in caring for patients receiving EN.

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Section: Appendix 1 Watermentioning

confidence: 99%

ASPEN Safe Practices for Enteral Nutrition Therapy

Boullata

Carrera²,

Harvey

et al. 2016

J Parenter Enteral Nutr

352

531

View full text Add to dashboard Cite

show abstract

“…End‐use devices (i.e., appliances, Table 1) also have internal water storage, and many become colonized by pathogens (Beach et al, 2003; Callewaert, Van Nevel, Kerckhof, Granitsiotis, & Boon, 2015; Garvey, Bradley, Tracey, & Oppenheim, 2016; Graman, Quinlan, & Rank, 1997; Ortolano et al, 2005; Sacchetti, De Luca, Guberti, & Zanetti, 2015). Yet, they are absent from some COVID‐19‐inspired building water system flushing guidance (Table 2).…”

Section: Resultsmentioning

confidence: 99%

“…Medical and dental facilities with specific sterile water or special application appliances (e.g., dialysis, heater–cooler machines) must be particularly carefully maintained and cleaned. Procedures and manufacturer protocols for these devices should always be consulted (Allen et al, 2017; Garvey et al, 2016; Muscarella, 2004; ProEdge Dental, 2020; van Ingen et al, 2017).…”

Section: Resultsmentioning

confidence: 99%

Considerations for large building water quality after extended stagnation

Proctor

Rhoads

Keane³

et al. 2020

AWWA Water Science

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The unprecedented number of building closures related to the coronavirus disease (COVID‐19) pandemic is concerning because water stagnation will occur in many buildings that do not have water management plans in place. Stagnant water can have chemical and microbiological contaminants that pose potential health risks to occupants. Health officials, building owners, utilities, and other entities are rapidly developing guidance to address this issue, but the scope, applicability, and details included in the guidance vary widely. To provide a primer of large building water system preventative and remedial strategies, peer‐reviewed, government, industry, and nonprofit literature relevant to water stagnation and decontamination practices for plumbing was synthesized. Preventative practices to help avoid the need for recommissioning (e.g., routine flushing) and specific actions, challenges, and limitations associated with recommissioning were identified and characterized. Considerations for worker and occupant safety were also indicated. The intended audience of this work includes organizations developing guidance.

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“…P. aeruginosa is not only one of the leading pathogens responsible for nosocomial infections [15][16][17][18], but also causes the morbidity and mortality of oncology and cystic fibrosis (CF) patients, where it is implicated in more than 90% of the occurrences of respiratory failure [19]. It is also prevalent in the burn units [20,21], the intensive care units causing ventilator-associated infections [22,23], and the neonatal intensive care units [24]. P. aeruginosa is the most prevalent isolate in intensive care units (ICUs), accounting for 23% of isolates, and the most common isolate taken from the human respiratory tract, accounting for 32% of isolates [25].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of iron oxide, iron nitride, and tobramycin conjugated nanoparticles against Pseudomonas aeruginosa biofilms

Armijo¹,

Wawrzyniec²,

Kopciuch³

et al. 2020

J Nanobiotechnol

128

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Background: Novel methods are necessary to reduce morbidity and mortality of patients suffering from infections with Pseudomonas aeruginosa. Being the most common infectious species of the Pseudomonas genus, P. aeruginosa is the primary Gram-negative etiology responsible for nosocomial infections. Due to the ubiquity and high adaptability of this species, an effective universal treatment method for P. aeruginosa infection still eludes investigators, despite the extensive research in this area. Results:We report bacterial inhibition by iron-oxide (nominally magnetite) nanoparticles (NPs) alone, having a mean hydrodynamic diameter of ~ 16 nm, as well as alginate-capped iron-oxide NPs. Alginate capping increased the average hydrodynamic diameter to ~ 230 nm. We also investigated alginate-capped iron-oxide NP-drug conjugates, with a practically unchanged hydrodynamic diameter of ~ 232 nm. Susceptibility and minimum inhibitory concentration (MIC) of the NPs, NP-tobramycin conjugates, and tobramycin alone were determined in the PAO1 bacterial colonies. Investigations into susceptibility using the disk diffusion method were done after 3 days of biofilm growth and after 60 days of growth. MIC of all compounds of interest was determined after 60-days of growth, to ensure thorough establishment of biofilm colonies. Conclusions:Positive inhibition is reported for uncapped and alginate-capped iron-oxide NPs, and the corresponding MICs are presented. We report zero susceptibility to iron-oxide NPs capped with polyethylene glycol, suggesting that the capping agent plays a major role in enabling bactericidal ability in of the nanocomposite. Our findings suggest that the alginate-coated nanocomposites investigated in this study have the potential to overcome the bacterial biofilm barrier. Magnetic field application increases the action, likely via enhanced diffusion of the iron-oxide NPs and NP-drug conjugates through mucin and alginate barriers, which are characteristic of cystic-fibrosis respiratory infections. We demonstrate that iron-oxide NPs coated with alginate, as well as alginate-coated magnetite-tobramycin conjugates inhibit P. aeruginosa growth and biofilm formation in established colonies. We have also determined that susceptibility to tobramycin decreases for longer culture times. However, susceptibility to the iron-oxide NP © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article' s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article'

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Continued transmission of Pseudomonas aeruginosa from a wash hand basin tap in a critical care unit

Cited by 42 publications

References 7 publications

ASPEN Safe Practices for Enteral Nutrition Therapy

ASPEN Safe Practices for Enteral Nutrition Therapy

Considerations for large building water quality after extended stagnation

Antibacterial activity of iron oxide, iron nitride, and tobramycin conjugated nanoparticles against Pseudomonas aeruginosa biofilms

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