“…In agreement with this study, a considerable number of studies have reported that COPD is a significant societal economic burden, associated with increased HCRU and higher health care costs, among COPD population versus control population. [18][19][20][21][22][23][24][25][26][27] As in our observations, previous studies have reported that key drivers for higher direct costs of COPD include inpatient hospitalizations 12,17,22,24,26,28 and increased medication use. 12,17,18,24 Further contributory factors to higher direct costs in COPD patients are comorbidities 17,19,23,27 and hospital admissions resulting from comorbidities.…”