Continuity resection of the mandible after ameloblastoma – feasibility of oral rehabilitation with rhBMP-2 associated to bovine xenograft followed by implant installation

Lustosa, Rômulo Maciel; Macedo, Diogo de Vasconcelos; Iwaki, Lílian Cristina Vessoni; Tolentino, Elen de Souza; Hasse, Paulo Norberto; Marson, Giordano Bruno de Oliveira; Filho, Liogi Iwaki

doi:10.1016/j.jcms.2015.06.030

Cited by 9 publications

(9 citation statements)

References 24 publications

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“…Once duplicates were removed, the abstracts of 408 articles were screened and 335 were considered ineligible. After reading the full text of 73 articles, 28 were excluded. Out of the remaining 45 articles, one study did not report on individual patient data of any parameter (neither baseline data nor outcome measures 16 ) and the attempt to procure the respective IPD directly from the author remained fruitless.…”

Section: Resultsmentioning

confidence: 99%

Segmental Mandibular Reconstruction Using Tissue Engineering Strategies: A Systematic Review of Individual Patient Data

Kumar

Rometsch²,

Thor

et al. 2020

Craniomaxillofacial Trauma & Reconstruction

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Objective: The aim of the systematic review was to analyze the current clinical evidence concerning the use of tissue engineering as a treatment strategy for reconstruction of segmental defects of the mandible and their clinical outcomes using individual patient data. Methods: A systematic review of the literature was conducted using PubMed and Cochrane Library on May 21, 2019. The eligibility criteria included patients in whom segmental mandibular reconstruction was carried out using tissue engineering as the primary treatment strategy. After screening and checking for eligibility, individual patient data were extracted to the extent it was available. Data extraction included the type of tissue engineering strategy, demographics, and indication for treatment, and outcomes included clinical and radiographic outcome measures, vitality of engineered bone, dental rehabilitation, and patient-reported outcome measures and complications. Results: Out of a total of 408 articles identified, 44 articles reporting on 285 patients were included, of which 179 patients fulfilled the inclusion criteria. The different tissue engineering treatment strategies could be broadly classified into 5 groups: “prefabrication,” “cell culture,” “bone morphogenetic protein (BMP) without autografts,” “BMP with autografts,” and “scaffolds containing autografts.” Most included studies were case reports or case series. A wide variety of components were used as scaffolds, cells, and biological substances. There was not a single outcome measure that was both objective and consistently reported, although most studies reported successful outcome. Discussion: A wide variety of tissue engineering strategies were used for segmental mandibular reconstruction that could be classified into 5 groups. Due to the low number of treated patients, lack of standardized and consistent reporting outcomes, lack of comparative studies, and low evidence of reported literature, there is insufficient evidence to recommend any particular tissue engineering strategy.

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Section: Resultsmentioning

confidence: 99%

Segmental Mandibular Reconstruction Using Tissue Engineering Strategies: A Systematic Review of Individual Patient Data

Kumar

Rometsch²,

Thor

et al. 2020

Craniomaxillofacial Trauma & Reconstruction

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“…Postsurgical defects may generate a significant morbidity that needs reconstruction and rehabilitation techniques to restore the oral functions of patients, increasing their quality of life [4]. Bone reconstruction can be achieved by flaps or bone regeneration materials [5].…”

Section: Introductionmentioning

confidence: 99%

Postsurgical Prosthetic Rehabilitation after Mandibular Ameloblastoma Resection: A 7-Year Follow-Up Case Report

Moreno-Soriano

Estrugo‐Devesa

Castañeda-Vega

et al. 2021

Case Reports in Dentistry

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Ameloblastomas are benign but locally invasive odontogenic tumors most frequently located in the mandible. The gold standard of treatment is the surgical resection of the tumor with safety margins. Postsurgical defects generate a significant morbidity that needs reconstruction and oral rehabilitation to restore the oral functions. This case report describes the prosthetic rehabilitation of a 42-year-old male after resection of a mandibular ameloblastoma. Excision of the lesion by segmental mandibulectomy and mandibular reconstruction by microvascularized fibula flap was performed. After placement of 6 dental implants, the patient was rehabilitated with a lower hybrid prosthesis fabricated using computer-aided design-computer-aided manufacturing. During a 7-year and 5-month follow-up, some clinical complications were observed.

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“…This excision may lead to a dramatic collapse of the patient's swallowing, pronunciation, chewing, and aesthetic functions, and the loss of anatomical structures will make the procedures of prosthetics difficult, especially in cases of the lower jaw, in addition to the deviation of the remaining segment toward the defect side which may lead to the loss of occlusal contacts on the defect side and a shift in the posterior functional contacts on the normal side [ 8 , 9 ]. Therefore, expeditiously rehabilitation after marginal or segmental mandibulectomy is preferred [ 10 , 11 ]. There are many techniques for the management of mandibular continuity defects such as nonvascularized bone graft, iliac crest free flap, and vascularized osseous free graft [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Possibility of Using Flexible Dentures over Iliac Bone Graft in Adolescent Patients with Ameloblastoma: A 9-Month Follow-Up Clinical Report

Belal¹,

Monther²,

Alzarif³

2021

Case Reports in Dentistry

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Introduction. The use of bone grafts is a common procedure after excision and reconstruction of the mandible, although it is rare in children and adolescents due to incomplete growth, which means a long transition period until reaching an appropriate age for implants or more predictable outcomes. Case Report. This article describes a 9-month follow-up of the use of a flexible denture above a bone graft taken from the anterior iliac crest for adolescent patients with resected mandible due to ameloblastoma. Taking into account prosthetic considerations, radiography, and clinical observation, no complications were seen with the graft. Conclusion. It is safe to use a flexible denture as a prosthetic over an iliac bone graft block during the healing period.

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Continuity resection of the mandible after ameloblastoma – feasibility of oral rehabilitation with rhBMP-2 associated to bovine xenograft followed by implant installation

Cited by 9 publications

References 24 publications

Segmental Mandibular Reconstruction Using Tissue Engineering Strategies: A Systematic Review of Individual Patient Data

Segmental Mandibular Reconstruction Using Tissue Engineering Strategies: A Systematic Review of Individual Patient Data

Postsurgical Prosthetic Rehabilitation after Mandibular Ameloblastoma Resection: A 7-Year Follow-Up Case Report

Possibility of Using Flexible Dentures over Iliac Bone Graft in Adolescent Patients with Ameloblastoma: A 9-Month Follow-Up Clinical Report

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