Continuous alfentanil infusion in pediatric patients undergoing general anesthesia for complete oral restoration

Davis, Peter J.; Chopyk, Jon-Bruce; Nazif, M M; Cook, D. Ryan

doi:10.1016/0952-8180(91)90112-z

Cited by 3 publications

(5 citation statements)

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“…The mean dose requirements for alfentanil(3.2 f 0.5 kg.kg-l.min-') were calculated by dividing the total dose of alfentanil by the patient's weight and the duration of anaesthesia. The dose requirement of alfentanil with nitrous oxide and oxygen is similar to that reported in adults and older children (White et al 1986;Davis et al 1991). Although patients in both groups had similar times to extubation, infants anaesthetized with alfentanil took s i e c a n t l y longer to be reactive after extubation than those anaesthetized with halothane.…”

Section: Discussionsupporting

confidence: 73%

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Continuous infusion of alfentanil in infants undergoing inguinal herniorraphy

Gronert

Davis

Cook

1992

Pediatric Anesthesia

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Summa yWe evaluated the safety and efficacy of continuous alfentanil infusions in 37 full-term infants aged 4 to 52 weeks undergoing inguinal herniorraphy as outpatients. The infants were randomly assigned to one of two groups. In all patients anaesthesia was induced with halothane, nitrous oxide and oxygen by mask, then atropine and atracurium were administered intravenously. In the alfentanil group, anaesthesia was maintained with nitrous oxide, oxygen and alfentanil (100 Fgkg-') followed by a 2.0 pg.kg-'-min-l continuous infusion whereas in the control group anaesthesia was maintained with nitrous oxide, oxygen, and halothane (1.5%). There were no differences between the groups with respect to intra-operative values of blood pressure and heart rate, post-operative values of oxygen saturation as measured by pulse oximetry and respiratory rate, or post-operative incidence of vomiting and use of pain medication. Sedation lasted longer post-operatively in the alfentanil group, delaying oral intake but not prolonging hospitalization time. This study affirms that intravenous anaesthesia with alfentanil is safe and effective in infants.

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Section: Discussionsupporting

confidence: 73%

“…Post-operative emesis was not associated with opioid anaesthesia in the babies we studied, but a high incidence of post-operative vomiting after alfentanil anaesthesia has been reported in adults and children (White et al 1986;Davis et al 1991). Age appears to be a major factor in post-operative emesis.…”

Section: Discussionmentioning

confidence: 59%

Continuous infusion of alfentanil in infants undergoing inguinal herniorraphy

Gronert

Davis

Cook

1992

Pediatric Anesthesia

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“…Alfentanil, an opioid analgesic agent, has been used for tooth extraction or complete oral restorations under general anesthesia in pediatric patients. 18,19 It may provide sedation and analgesia and may be related to a high rate of postoperative vomiting, as with all opioids. In our study, alfentanil was associated with a 10.5% incidence of nausea-vomiting, which was two-fold higher than with propofol.…”

Section: Discussionmentioning

confidence: 99%

Retrospective evaluation of sedation techniques for tooth extraction in pediatric patients

Canpolat¹,

Kütük²,

Asan³

et al. 2018

Cumhuriyet Dental Journal

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Objective: Due to lack of past experiences and cooperation in anxious and fearful children, tooth extraction may be difficult to manage in dentistry. The aims of this retrospective study were to evaluate the various sedation techniques, complications and the characteristics of children whose tooth extraction were performed with deep sedation. Materials and Methods:After approval by the Local Ethics Committee, a retrospective analysis was performed using the records of 885 patients who were treated with deep sedation for tooth extraction between the ages of 1-15 years for the period between 2012 and 2014The authors described the characteristics of the children, the sedation techniques used; and the complications. Results:The mean weight of the patients was 20.09±7.3 kg and the mean age was 5.72±2.5 years. The mean duration of the operations was 16.14±5.4 minutes. Propofol, ketamine, propofol-ketamine combination, alfentanil, midazolam, sevoflurane inhalation, sevoflurane inhalation + propofol were used for the anesthesia. There were no statistically significant differences among the anesthetic agents for post-operative complications (p>0.05). Conclusions:We concluded that propofol was a better option for deep sedation in pediatric dental extraction due to short duration time, rapid recovery and less nauseavomiting. Ketamine-propofol combination may be used as an alternative to propofol alone.

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“…7 In addition to neuromuscular antagonists, Dr Cook and his team helped define the pharmacology of opioids like alfentanil in the pediatric population. [17][18][19][20][21] Alfentanil has a rapid onset of analgesia and has a shorter elimination half-life than fentanyl and sufentanil, but these parameters had not previously been defined in neonates. Dr…”

Section: During Dr Cook's Third Year Of Medical School He Was Hired mentioning

confidence: 99%

“…Postoperative vomiting in children was a significant issue related to alfentanil and likely contributed to delayed discharge times. 20 Pediatric patients undergoing liver transplantation potentially metabolize and eliminate opioids differently because of a dysfunctional liver or increased intra-abdominal pressure (from ascites). Dr…”

Section: During Dr Cook's Third Year Of Medical School He Was Hired mentioning

confidence: 99%

The advancement of pediatric anesthesia pharmacology: David Ryan Cook (scions, serendipity, and six degrees of separation)

Cladis

Christine

Yaster

et al. 2018

Pediatric Anesthesia

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Summary Dr David Ryan Cook, Professor Emeritus of Anesthesiology and Pharmacology at the University of Pittsburgh and Chief of Anesthesiology at Children's Hospital of Pittsburgh (1977‐1999), is a pioneer in the field of pediatric anesthesiology and pharmacology. Dr Cook contributed significantly to the understanding of pharmacologic differences among infants, children, and adults. His work as a clinician‐scientist, educator, and mentor defined the pharmacology of many of the anesthetic agents we continue to use today. He brought science to the art of anesthesia and enhanced the safety of pediatric perioperative care. Based on a 2017 interview with Dr Cook, this article outlines the development of his career and his contributions to the field of anesthesiology and pharmacology.

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Continuous alfentanil infusion in pediatric patients undergoing general anesthesia for complete oral restoration

Cited by 3 publications

References 0 publications

Continuous infusion of alfentanil in infants undergoing inguinal herniorraphy

Continuous infusion of alfentanil in infants undergoing inguinal herniorraphy

Retrospective evaluation of sedation techniques for tooth extraction in pediatric patients

The advancement of pediatric anesthesia pharmacology: David Ryan Cook (scions, serendipity, and six degrees of separation)

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