Continuous and intermittent parathyroid hormone administration promotes osteogenic differentiation and activity of programmable cells of monocytic origin

Kir, MC; Onal, Melike Ozgul; Uluer, ET; Ulman, Cevval; İnan, Sevinç

doi:10.1080/10520295.2022.2049876

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…(1) Cellular actions of PTH contribute to increased bone formation: anabolism of bone Both animal and clinical studies have found that iPTH is effective in promoting bone formation. Daily administration of PTH, as well as PTHrP, injections has been found to reduce apoptosis in osteoblasts and osteocytes while simultaneously increasing the number of osteoblasts [95][96][97][98]. This leads to a higher activation frequency and rate of bone formation, culminating in improved bone mineral density and enhanced bone strength [99].…”

Section: Osteoblasts and Osteocytes As Targetsmentioning

confidence: 99%

PTH and the Regulation of Mesenchymal Cells within the Bone Marrow Niche

Liu,

Rosen

2024

Cells

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Parathyroid hormone (PTH) plays a pivotal role in maintaining calcium homeostasis, largely by modulating bone remodeling processes. Its effects on bone are notably dependent on the duration and frequency of exposure. Specifically, PTH can initiate both bone formation and resorption, with the outcome being influenced by the manner of PTH administration: continuous or intermittent. In continuous administration, PTH tends to promote bone resorption, possibly by regulating certain genes within bone cells. Conversely, intermittent exposure generally favors bone formation, possibly through transient gene activation. PTH’s role extends to various aspects of bone cell activity. It directly influences skeletal stem cells, osteoblastic lineage cells, osteocytes, and T cells, playing a critical role in bone generation. Simultaneously, it indirectly affects osteoclast precursor cells and osteoclasts, and has a direct impact on T cells, contributing to its role in bone resorption. Despite these insights, the intricate mechanisms through which PTH acts within the bone marrow niche are not entirely understood. This article reviews the dual roles of PTH—catabolic and anabolic—on bone cells, highlighting the cellular and molecular pathways involved in these processes. The complex interplay of these factors in bone remodeling underscores the need for further investigation to fully comprehend PTH’s multifaceted influence on bone health.

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Section: Osteoblasts and Osteocytes As Targetsmentioning

confidence: 99%

PTH and the Regulation of Mesenchymal Cells within the Bone Marrow Niche

Liu,

Rosen

2024

Cells

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Comparative clinical study of phosphorous necrosis and medical-related osteonecrosis of the jaws

Xie,

Wang,

Bian

et al. 2024

Clin Oral Invest

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Background: Phosphorous necrosis of the jaw (PNJ) shares similar clinical and pathological features to medical-related osteonecrosis of the jaw (MRONJ). This study aims to compare the similarities and differences between PNJ and medical-related osteonecrosis of the jaw (MRONJ) in terms of clinical and pathological features, and to provide a theoretical basis for the clinical diagnosis and management of PNJ.Material and Methods: A retrospective analysis assessed clinical differences among 38 PNJ patients and 31 MRONJ patients diagnosed and treated between January 2009 and October 2022. Pathological alterations in bone tissue were assessed using EDS, H&E, Masson and TRAP staining on ve specimens from both MRONJ and PNJ cases, and immunohistochemistry was used to determine the expression levels of OPG, RANKL, and Runx2. The mandibular coronoid process was removed from individuals with temporomandibular joint ankylosis as control.Results: CBCT imaging indicated necrotic bone formation in block, strip, or plaque shapes. EDS analysis revealed that the calcium/phosphorus ratio in the bone tissue of PNJ and MRONJ was signi cantly lower than that of the control group (P<0.05). Additionally, staining indicated reduced osteoblast counts, disrupted bone trabecular structure, and decreased collagen ber content in the bone tissues of PNJ and MRONJ. Immunohistochemistry revealed that RANKL expression was signi cantly lower in MRONJ compared to PNJ and control groups (P<0.05). Conversely, Runx2 expression was signi cantly higher in PNJ than in MRONJ and control groups (P<0.05), with no signi cant difference in OPG expression.Conclusion: PNJ and MRONJ exhibit comparable clinical manifestations and pathological traits, although disparities may exist in their underlyingexhibit comparable clinical manifestations and pathological traits, although disparities may exist in their underlying molecular mechanisms.

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Comparative clinical study of phosphorous-necrosis and medical-related osteonecrosis of the jaws

Xie,

Wang,

Bian

et al. 2023

Preprint

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Background: Phosphorous necrosis of the jaw (PNJ) shares similar clinical and pathological features to medical-related osteonecrosis of the jaw (MRONJ). This study aims to compare the similarities and differences between PNJ and medical-related osteonecrosis of the jaw (MRONJ) in terms of clinical and pathological features, and to provide a theoretical basis for the clinical diagnosis and management of PNJ. Material and Methods: A retrospective analysis assessed clinical differences among 38 PNJ patients and 31 MRONJ patients diagnosed and treated between January 2009 and October 2022. Pathological alterations in bone tissue were assessed using EDS, H&E, Masson and TRAP staining on five specimens from both MRONJ and PNJ cases, and immunohistochemistry was used to determine the expression levels of OPG, RANKL, and Runx2. The mandibular coronoid process was removed from individuals with temporomandibular joint ankylosis as control. Results: CBCT imaging indicated necrotic bone formation in block, strip, or plaque shapes. EDS analysis revealed that the calcium/phosphorus ratio in the bone tissue of PNJ and MRONJ was significantly lower than that of the control group (P<0.05). Additionally, staining indicated reduced osteoblast counts, disrupted bone trabecular structure, and decreased collagen fiber content in the bone tissues of PNJ and MRONJ. Immunohistochemistry revealed that RANKL expression was significantly lower in MRONJ compared to PNJ and control groups (P<0.05). Conversely, Runx2 expression was significantly higher in PNJ than in MRONJ and control groups (P<0.05), with no significant difference in OPG expression. Conclusion: PNJ and MRONJ exhibit comparable clinical manifestations and pathological traits, although disparities may exist in their underlyingexhibit comparable clinical manifestations and pathological traits, although disparities may exist in their underlying molecular mechanisms.

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Continuous and intermittent parathyroid hormone administration promotes osteogenic differentiation and activity of programmable cells of monocytic origin

Cited by 3 publications

References 36 publications

PTH and the Regulation of Mesenchymal Cells within the Bone Marrow Niche

PTH and the Regulation of Mesenchymal Cells within the Bone Marrow Niche

Comparative clinical study of phosphorous necrosis and medical-related osteonecrosis of the jaws

Comparative clinical study of phosphorous-necrosis and medical-related osteonecrosis of the jaws

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