Continuous Bladder Irrigation With Vancomycin for the Treatment of Methicelun‐resistant Staphylococcus Aureus

Hajjar, Ramzi R.; Philpot, Carolyn D.; Morley, John E.

doi:10.1111/j.1532-5415.1996.tb03760.x

Cited by 7 publications

(6 citation statements)

References 6 publications

(5 reference statements)

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“…The earlier reports on IVA date back to 1967 when most studies were case reports. It was in 1996 that Hajjar et al described a strain of resistant bacteria due to indiscriminate antibiotic use and reported a case of vancomycin bladder irrigation (via a three-way catheter) to treat MRSA [ 18 ]. Then, in 1978, Haldorson et al tested the use of neomycin in reducing bacteriuria in a case-control group after ISC [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

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Use and Effectiveness of Antimicrobial Intravesical Treatment for Prophylaxis and Treatment of Recurrent Urinary Tract Infections (UTIs): a Systematic Review

et al. 2018

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Purpose of ReviewIntravesical antibiotics (IVA) has been used for prophylaxis and treatment of recurrent urinary tract infections (rUTIs). However, there is a lack of comprehensive evidence and consensus on its use. We conducted a systematic review to collect all available data about the effectiveness of IVA in prevention and treatment of rUTIs and to give an overview on the outcomes to date.MethodsA systematic review was carried out for all English language articles from inception to August 2017, according to the Cochrane and PRISMA standards using MEDLINE, Scopus, Biomed Central, EMBASE, CINAHL, and Web of Science with references cross-checked and individual urology journals hand-searched.ResultsAfter an initial identification of 658 studies, we screened 37 abstracts and 18 full-text papers of which 11 were included in our final review. This included 285 patients with a mean age of 52 years and a female:male ratio of 129:117. The IVA used was gentamicin, neomycin/polymyxin, neomycin or colistin and IVA was used for rUTIs as prophylaxis in 5 studies (n = 168) and treatment in 6 studies (n = 117). Overall, a good reduction in symptomatic UTI was seen in 78%, with a short-term success rate and discontinuation rates of 71% (120/168) and 8% (14/168) in the prophylaxis group and 88% (103/117) and 5% (6/117) in the treatment groups respectively. There was a change in the sensitivity of organisms in 30% (50/168) and 23% (27/117) in the treatment and prophylaxis groups respectively. Twenty patients discontinued their IVA instillations which were higher for the non-gentamicin group (11%) compared to the gentamicin group (5%). The side effects were minor and included allergy, suprapubic discomfort, autonomic dysreflexia, urinary tract infections and diarrhoea.SummaryIntravesical antimicrobial instillation seems to be a relatively safe and effective method for the prophylaxis and treatment of recurrent UTIs, especially in the short term. It gives clinicians an alternative treatment modality in high-risk patients predisposed to UTIs where all other forms of systemic treatments have failed.

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Section: Discussionmentioning

confidence: 99%

“…During our literature research, we also identified other antimicrobials such as tobramicin, linezolid and vancomycin which have been used as IVA. However, these results were mostly limited to isolated case reports [ 12 , 14 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

Use and Effectiveness of Antimicrobial Intravesical Treatment for Prophylaxis and Treatment of Recurrent Urinary Tract Infections (UTIs): a Systematic Review

et al. 2018

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“…The only 3 previous reports of bladder irrigations for treating bacterial UTIs showed variable efficacy (∼50%) in less ill patients (total n = 25). 3–5 In our patient, adjunctive tobramycin bladder irrigation was safe and effective for treating a lower UTI. Although more data are needed, bladder irrigation may be an option for localized infections when systemic therapy is undesirable.…”

mentioning

confidence: 65%

Tobramycin Bladder Irrigation for Treating a Urinary Tract Infection in a Critically Ill Patient

et al. 2004

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“…A case series of two women with urinary retention and recurrent UTIs by Van Nieuwkoop using a higher dose of intravesical gentamicin (80 mg daily), showed negative cultures during 8 and 9 months of treatment and no clinical side effects (52). Of note, gentamicin remains the only agent for which substantial series exist in which intravesical therapy was used for treatment of UTI, as all data regarding other antibiotics is limited to individual case reports (53-55). …”

Section: Historical and Contemporary Use Of Intravesical Agentsmentioning

confidence: 99%

Recurrent urinary tract infections in patients with incomplete bladder emptying: is there a role for intravesical therapy?

Dray¹,

Clemens²

2017

Transl. Androl. Urol.

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The goal of this review article is to discuss the etiology of recurrent urinary tract infections (UTIs) in individuals with impaired bladder emptying, evaluate existing studies regarding UTI prevention strategies in this population, and explore the published experiences with intravesical therapy for the prevention and treatment of recurrent UTIs in patients performing clean intermittent catheterization (CIC). We will also describe the intravesical antibiotic protocol utilized at our institution.

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Continuous Bladder Irrigation With Vancomycin for the Treatment of Methicelun‐resistant Staphylococcus Aureus

Cited by 7 publications

References 6 publications

Use and Effectiveness of Antimicrobial Intravesical Treatment for Prophylaxis and Treatment of Recurrent Urinary Tract Infections (UTIs): a Systematic Review

Use and Effectiveness of Antimicrobial Intravesical Treatment for Prophylaxis and Treatment of Recurrent Urinary Tract Infections (UTIs): a Systematic Review

Tobramycin Bladder Irrigation for Treating a Urinary Tract Infection in a Critically Ill Patient

Recurrent urinary tract infections in patients with incomplete bladder emptying: is there a role for intravesical therapy?

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