Continuous cognitive improvement 1 year following successful kidney transplant

Harciarek, Michał; Biedunkiewicz, Bogdan; Lichodziejewska‐Niemierko, Monika; Dębska-Ślizień, Alicja; Rutkowski, Bolesław

doi:10.1038/ki.2011.40

Cited by 70 publications

(84 citation statements)

References 47 publications

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“…The default mode network and the sensorimotor network remained statistically different from controls even 6 months after kidney transplantation. These findings provide neural substrates for different brain cognition function recovery patterns in accordance with previously reported results (8,11). Different networks are responsible for distinct domains of brain function.…”

Section: Discussionsupporting

confidence: 81%

“…Previous studies showed that some domains of cognition function, especially memory, did not fully return to normal until 1 year after successful kidney transplantation (8). The default mode network is involved in numerous brain functions, including memory, visual and Figure 4.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies showed that successful kidney transplantation can lead to improvement in the cognitive performance of patients with ESRD (8)(9)(10). However, it has also been shown that not all cognition domains recover simultaneously after successful kidney transplantation (8,11).…”

Section: Introductionmentioning

confidence: 99%

“…However, it has also been shown that not all cognition domains recover simultaneously after successful kidney transplantation (8,11). Harciarek et al (8) reported that psychomotor speed, visual planning, retrieval of learned material, and abstract thinking were improved in patients 1 month after kidney transplantation, whereas memory function improvement was generally not observed until 1 year after kidney transplantation. However, possible neural mechanism remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Re-Establishing Brain Networks in Patients with ESRD after Successful Kidney Transplantation

Chen¹,

Wen

Qi³

et al. 2017

CJASN

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Background and objectives Cognition in ESRD may be improved by kidney transplantation, but mechanisms are unclear. We explored patterns of resting-state networks with resting-state functional magnetic resonance imaging among patients with ESRD before and after kidney transplantation.Design, setting, participants, & measurements Thirty-seven patients with ESRD scheduled for kidney transplantation and 22 age-, sex-, and education-matched healthy subjects underwent resting-state functional magnetic resonance imaging. Patients were imaged before and 1 and 6 months after kidney transplantation. Functional connectivity of seven resting-state subnetworks was evaluated: default mode network, dorsal attention network, central executive network, self-referential network, sensorimotor network, visual network, and auditory network. Mixed effects models tested associations of ESRD, kidney transplantation, and neuropsychological measurements with functional connectivity.Results Compared with controls, pretransplant patients showed abnormal functional connectivity in six subnetworks. Compared with pretransplant patients, increased functional connectivity was observed in the default mode network, the dorsal attention network, the central executive network, the sensorimotor network, the auditory network, and the visual network 1 and 6 months after kidney transplantation (P=0.01). Six months after kidney transplantation, no significant difference in functional connectivity was observed for the dorsal attention network, the central executive network, the auditory network, or the visual network between patients and controls. Default mode network and sensorimotor network remained significantly different from those in controls when assessed 6 months after kidney transplantation. A relationship between functional connectivity and neuropsychological measurements was found in specific brain regions of some brain networks. ConclusionsThe recovery patterns of resting-state subnetworks vary after kidney transplantation. The dorsal attention network, the central executive network, the auditory network, and the visual network recovered to normal levels, whereas the default mode network and the sensorimotor network did not recover completely 6 months after kidney transplantation. Neural resting-state functional connectivity was lower among patients with ESRD compared with control subjects, but it significantly improved with kidney transplantation. Resting-state subnetworks exhibited variable recovery, in some cases to levels that were no longer significantly different from those of normal controls.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Re-Establishing Brain Networks in Patients with ESRD after Successful Kidney Transplantation

Chen¹,

Wen

Qi³

et al. 2017

CJASN

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“…Successful transplantation, which can restore solute clearances to more than half normal, improves overall quality of life and enhances specific functions, including sleep, cognition, exercise capacity, and growth in children. [5][6][7][8][9] …”

mentioning

confidence: 99%

Approaches to Uremia

Meyer

Hostetter

2014

Journal of the American Society of Nephrology

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The development of dialysis was a dramatic step forward in medicine, allowing people who would soon have died because of lack of kidney function to remain alive for years. We have since found, however, that the "artificial kidney" does not live up fully to its name. Dialysis keeps patients alive but not well. Part of the residual illness that dialysis patients experience is caused by retained waste solutes that dialysis does not remove as well as native kidney function does. New means are available to identify these toxic solutes, about which we currently know remarkably little, and knowledge of these solutes would help us to improve therapy. This review summarizes our current knowledge of toxic solutes and highlights methods being explored to identify additional toxic solutes and to enhance the clearance of these solutes to improve patient outcomes.

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Functional–structural relationship in large‐scale brain networks of patients with end stage renal disease after kidney transplantation: A longitudinal study

Chen

Wang

Wen

et al. 2019

Human Brain Mapping

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It is unclear how the brain network changed after kidney transplantation (KT). We explored the patterns of large‐scale complex network after KT in end‐stage renal disease (ESRD) patients with resting‐state functional MRI (rs‐fMRI) and diffusion tensor imaging (DTI). Twenty‐one ESRD patients (14 men; mean age, 31.5 ± 9.9 years) scheduled for KT and 17 age‐ and gender‐matched healthy controls (HC) (8 men; mean age, 28.9 ± 7.2 years) were enrolled in this study. Each participant underwent rs‐fMRI and DTI scans in three time points (pre‐KT, 1 and 6 months after KT [for ESRD]). Graph theory analysis was used to characterize the topological properties by using functional and structural network connectivities intergroup correlation analysis was performed between functional/structural MR indexes and clinical markers. Compared with HC, pre‐KT ESRD patients showed an altered topological organization in both functional and structural networks. Compared with pre‐KT, increased node degree and node efficiency were observed for both functional and structural networks at 1 month after KT (all p < .05), which were further increased at 6 months after KT (p < .05). Both functional and structural networks did not recover completely at 6 months after KT (all p < .05). The patients showed an increased functional–structural connectivity coupling at 1 month after KT compared with HC (p = .041). A trend of progressive recovery of functional and structural connectivity networks was observed in ERSD patients after KT, which did not recover to the normal levels even in 6 months after KT. The study results underlie cognitive function recovery in ESRD patients following KT in the neuropathophysiological perspective.

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Continuous cognitive improvement 1 year following successful kidney transplant

Cited by 70 publications

References 47 publications

Re-Establishing Brain Networks in Patients with ESRD after Successful Kidney Transplantation

Re-Establishing Brain Networks in Patients with ESRD after Successful Kidney Transplantation

Approaches to Uremia

Functional–structural relationship in large‐scale brain networks of patients with end stage renal disease after kidney transplantation: A longitudinal study

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