2016
DOI: 10.1038/cddis.2016.157
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Continuous exposure of pancreatic cancer cells to dietary bioactive agents does not induce drug resistance unlike chemotherapy

Abstract: The repeated treatment of cancer cells with chemo- or radiotherapy induces therapy resistance, but it was previously unknown whether the same effect occurs upon continuous exposure of cancer cells to diet-derived chemopreventive agents. We elucidated this interesting question in pancreatic ductal adenocarcinoma, which is a highly aggressive cancer entity with a marked resistance toward gemcitabine and other cytotoxic drugs. The isothiocyanate sulforaphane, present in cruciferous vegetables, and the polyphenol … Show more

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Cited by 43 publications
(25 citation statements)
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“…Recent data suggest that the broccoliderived bioactive agent sulforaphane may enhance the therapeutic efficacy of cytotoxic therapy. Sulforaphane weakens cancer stem cells, which are considered the bases of tumour growth and metastasis [3][4][5][6]. Currently, there is no drug with purified sulforaphane.…”
Section: Introductionmentioning
confidence: 99%
“…Recent data suggest that the broccoliderived bioactive agent sulforaphane may enhance the therapeutic efficacy of cytotoxic therapy. Sulforaphane weakens cancer stem cells, which are considered the bases of tumour growth and metastasis [3][4][5][6]. Currently, there is no drug with purified sulforaphane.…”
Section: Introductionmentioning
confidence: 99%
“…Especially the isothiocyanate sulforaphane, which is enriched in broccoli, is well examined regarding it´s cancer inhibitory and chemotherapy-supporting effects. Our data demonstrate that sulforaphane even breaks the resistance of the highly aggressive cancer stem cells [18]. This small population of progenitor cells is found in pancreatic cancer and other tumor entities and is made responsible for tumor growth, therapy resistance and metastasis.…”
Section: Ingrid Herrmentioning
confidence: 92%
“…The human established PDA cell lines BxPc-3, AsPC-1 and PANC-1 were purchased from the American Type Culture Collection (ATCC, Manassas, VA, USA). The gemcitabine-resistant cell line Bx-Gem was established in our laboratory based on BxPc-3 as described previously [6]. All cell lines were authenticated by a commercial institution (Multiplexion, Heidelberg, Germany) and tested monthly for mycoplasma by PlasmoTest™ (InvivoGen, San Diego, USA).…”
Section: Tumour Cell Linesmentioning
confidence: 99%