We explore large-scale cosmic structure using the spatial distribution of 542 gamma-ray bursts (GRBs) having accurately measured positions and spectroscopic redshifts. Prominent cosmological clusters are identified in both the northern and southern galactic hemispheres (avoiding extinction effects in the plane of the Milky Way) using the bootstrap point-radius method. The northern galactic hemisphere contains a significant group of four GRBs in the redshift range 0.59 ≤ z ≤ 0.62 (with a bootstrap probability of p = 0.012) along with the previously identified Hercules–Corona Borealis Great Wall (in the revised redshift range 0.9 ≤ z ≤ 2.1; p = 0.017). The southern galactic hemisphere contains the previously identified Giant GRB Ring (p = 0.022) along with another possible cluster of seven to nine GRBs at 1.17 ≤ z ≤ 1.444 (p = 0.031). Additionally, both the Hercules–Corona Borealis Great Wall and the Giant GRB Ring have become more prominent as the GRB sample size has grown. The approach used here underscores the potential value of GRB clustering as a probe of large-scale cosmic structure, complementary to galaxy and quasar clustering. Because of the vast scale on which GRB clustering provides valuable insights, it is important that optical GRB monitoring continues so that additional spectroscopic redshift measurements could be obtained.