2018
DOI: 10.1039/c7cs00906b
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Continuous flow biocatalysis

Abstract: The continuous flow synthesis of active pharmaceutical ingredients, value-added chemicals, and materials has grown tremendously over the past ten years. This revolution in chemical manufacturing has resulted from innovations in both new methodology and technology. This field, however, has been predominantly focused on synthetic organic chemistry, and the use of biocatalysts in continuous flow systems is only now becoming popular. Although immobilized enzymes and whole cells in batch systems are common, their c… Show more

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Cited by 303 publications
(258 citation statements)
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“…Furthermore, there is a need of innovating in process technology areas, to increase the productivity of chemical reactions while reducing by product formation at the same time. These needs have stimulated the development of continuous biocatalytic reactions, becoming an increasingly important trend, as comprehensively reviewed elsewhere . Different reactor types have been used with enzymes, starting from the non‐continuous batch reactor– the most used one–, to ultimately put forth semi‐continuous, fed‐batch, fluidized bed and packed‐bed continuous reactors for biocatalysis (Figure ).…”
Section: Motivation Synergies Among Biocatalysis Environmentally‐frmentioning
confidence: 99%
“…Furthermore, there is a need of innovating in process technology areas, to increase the productivity of chemical reactions while reducing by product formation at the same time. These needs have stimulated the development of continuous biocatalytic reactions, becoming an increasingly important trend, as comprehensively reviewed elsewhere . Different reactor types have been used with enzymes, starting from the non‐continuous batch reactor– the most used one–, to ultimately put forth semi‐continuous, fed‐batch, fluidized bed and packed‐bed continuous reactors for biocatalysis (Figure ).…”
Section: Motivation Synergies Among Biocatalysis Environmentally‐frmentioning
confidence: 99%
“…Powdery materials can be used as carriers and packed in a fixed bed reactor as well as porous monoliths, which have been successfully used for ATA immobilization . Flow chemistry, along with enzyme immobilization, can circumvent some critical issues of biocatalytic reactions, thus positively influencing the outcome of the biotransformation . In particular, whereas enzyme immobilization can improve enzyme stability, operating under flow‐conditions can significantly reduce substrate/product inhibition effects and push forward unfavorable reaction equilibria through the continuous removal of the product from the reaction site.…”
Section: Introductionmentioning
confidence: 99%
“…In recent years, enzymatic processes have offered many merits, including mild reaction conditions and avoidance of toxic and hazardous organic reagents . Some enzymes, including laccase, horseradish peroxidase and orange II azoreductase, have already been applied for the degradation of azo dyes . However, problems of low stability, high cost and non‐reusability of free enzymes have hampered their industrialization in wastewater treatment.…”
Section: Introductionmentioning
confidence: 99%
“…In the past decade, continuous flow reactors based on monolithic biocatalysts have attracted much attention owing to their in‐line purification, improved mixing and mass transfer, etc . In general, a monolithic biocatalyst consists of a monolithic scaffold and an immobilized enzyme.…”
Section: Introductionmentioning
confidence: 99%