2013
DOI: 10.1021/op400138v
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Continuous Flow Multipoint Dosing Approach for Selectivity Engineering in Sulfoxidation

Abstract: A continuous synthesis approach with multipoint dosing of one of the reagents is demonstrated for the synthesis of sulfoxide compounds such as proton pump inhibitors. Use of multipoint dosing of the oxidizing agent helped to minimize the possibility of over-oxidation leading to sulfone. Different oxidizing agents were used, and the effect of various parameters (viz. mole ratio of sulfide to oxidizing agent, temperature, residence time, concentration of oxidizing agent, etc.) on the yield of the desired sulfoxi… Show more

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Cited by 9 publications
(7 citation statements)
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“…A simple size-up approach to increase the inner volume of a single reactor with a larger diameter microchannel produced lower mixing efficiency, which requires incorporation of unique types of extra mixers for ultrafast chemistry, as reported. However, it is still problematic to manage the pressure drop issue at high flow rates in the extended length of a reactor for achieving a large scale of production . Therefore, the numbering-up strategy of aligning multiple microreactors in parallel or in a stack is considered to be the most effective for increasing the overall throughput. For numbering-up microreactors to carry out effective ultrafast chemistry, an advanced approach is required to devise a simple design of a microreactor with excellent mixing efficiency, instead of the complex and nonplanar channel structures that make it difficult to manufacture a laminated structure. Furthermore, it is essential to evenly feed the reagents into the laminated microreactors to ensure equivalent ultrafast synthesis under the optimized conditions.…”
Section: Introductionmentioning
confidence: 99%
“…A simple size-up approach to increase the inner volume of a single reactor with a larger diameter microchannel produced lower mixing efficiency, which requires incorporation of unique types of extra mixers for ultrafast chemistry, as reported. However, it is still problematic to manage the pressure drop issue at high flow rates in the extended length of a reactor for achieving a large scale of production . Therefore, the numbering-up strategy of aligning multiple microreactors in parallel or in a stack is considered to be the most effective for increasing the overall throughput. For numbering-up microreactors to carry out effective ultrafast chemistry, an advanced approach is required to devise a simple design of a microreactor with excellent mixing efficiency, instead of the complex and nonplanar channel structures that make it difficult to manufacture a laminated structure. Furthermore, it is essential to evenly feed the reagents into the laminated microreactors to ensure equivalent ultrafast synthesis under the optimized conditions.…”
Section: Introductionmentioning
confidence: 99%
“…The yield of such intermediates (if i.e., the desired product) depends on the relative rates of the reactions, which further depends on the concentration and the reaction temperature. A few important examples include organometallic reactions, halogenations, oxidation, nitration, and so forth. Usually, the excess amount of one of the reagents or higher reactivity of the desired intermediate leads to side reactions. Higher conversion results in the formation of both undesired and desired products, thereby reducing the selectivity and yield of the desired product.…”
Section: Introductionmentioning
confidence: 99%
“…Distributed dosing is one of the popular ways to address this problem, where the limiting concentration of one of the reagents helps in getting better control over the selectivity of the desired product. In recent times, few such examples are reported in the literature. ,, A multipoint injection system can help to overcome this issue, where one of the reagents is dosed at multiple locations along the reactor length, leading to the membrane reactor as an extreme case . One of the main reaction parameters driving selectivity is the temperature of reactants.…”
Section: Introductionmentioning
confidence: 99%
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