Continuous Flow Science in an Undergraduate Teaching Laboratory: Bleach-Mediated Oxidation in a Biphasic System

Kairouz, Vanessa; Collins, Shawn K.

doi:10.1021/acs.jchemed.7b00412

Cited by 13 publications

(11 citation statements)

References 11 publications

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“…In fact, PTC-assisted oxidations have been comprehensively reviewed . The simple setup and relatively safe reagent combination makes the approach particularly attractive [329].…”

Section: Oxidation and Related Transformationsmentioning

confidence: 99%

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A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

Gambacorta¹,

Sharley²,

Baxendale³

2021

Beilstein J. Org. Chem.

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Due to their intrinsic physical properties, which includes being able to perform as volatile liquids at room and biological temperatures, fragrance ingredients/intermediates make ideal candidates for continuous-flow manufacturing. This review highlights the potential crossover between a multibillion dollar industry and the flourishing sub-field of flow chemistry evolving within the discipline of organic synthesis. This is illustrated through selected examples of industrially important transformations specific to the fragrances and flavours industry and by highlighting the advantages of conducting these transformations by using a flow approach. This review is designed to be a compendium of techniques and apparatus already published in the chemical and engineering literature which would constitute a known solution or inspiration for commonly encountered procedures in the manufacture of fragrance and flavour chemicals.

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“…In fact, PTC-assisted oxidations have been comprehensively reviewed . The simple setup and relatively safe reagent combination makes the approach particularly attractive [329].…”

Section: Oxidation and Related Transformationsmentioning

confidence: 99%

“…As an example, the use of bleach and catalytic tetrabutylammonium bromide (TBAB) for the oxidation of alcohols and aldehydes in flow was reported by Jamison et al in 2012 ( Scheme 81 ) [ 328 ]. The simple setup and relatively safe reagent combination makes the approach particularly attractive [ 329 ].…”

Section: Reviewmentioning

confidence: 99%

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

Gambacorta¹,

Sharley²,

Baxendale³

2021

Beilstein J. Org. Chem.

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“…(B) Examples of reactions showcasing green chemistry under flow conditions include the synthesis of 5-hydroxymethylfurfural (6) from fructose (5) 32 and the conversion of reclaimed vegetable oil into biodiesel (not shown). 33 (C) Oxidation reactions under flow conditions on a preparation scale have been developed by Kairouz and Collins 34 and by the Leadbeater group 21 based on work developed by the Jamison group. 35 In both cases, a benzylic aldehyde was oxidised to a methyl ester using aqueous NaOCl in the presence of tetrabutylammonium bromide.…”

Section: Spotlight Synopenmentioning

confidence: 99%

Recent Advances Towards the Inclusion of Flow Chemistry within the Undergraduate Practical Class Curriculum

Cranwell¹

2020

SynOpen

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“…Hence, there is a high demand for skilled personnel with at least a notion of flow chemistry. It is therefore obvious that flow chemistry courses should be implemented in the academic training of future generations of chemists and chemical engineers [20][21][22][23][24][25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Flow chemistry experiments in the undergraduate teaching laboratory: synthesis of diazo dyes and disulfides

et al. 2020

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By embedding flow technology in the early phases of academic education, students are exposed to both the theoretical and practical aspects of this modern and widely-used technology. Herein, two laboratory flow experiments are described which have been carried out by first year undergraduate students at Eindhoven University of Technology. The experiments are designed to be relatively risk-free and they exploit widely available equipment and cheap capillary flow reactors. The experiments allow students to develop a hands-on understanding of continuous processing and gives them insights in both organic chemistry and chemical engineering. Furthermore, they learn about the benefits of microreactors, continuous processing, multistep reaction sequences and multiphase chemistry. Undoubtedly, such skills are highly valued in both academia and the chemical industry.

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Continuous Flow Science in an Undergraduate Teaching Laboratory: Bleach-Mediated Oxidation in a Biphasic System

Cited by 13 publications

References 11 publications

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

Recent Advances Towards the Inclusion of Flow Chemistry within the Undergraduate Practical Class Curriculum

Flow chemistry experiments in the undergraduate teaching laboratory: synthesis of diazo dyes and disulfides

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