Abstract:The first continuous flow method was developed for the synthesis of 6-monoamino-6-monodeoxy-β-cyclodextrin starting from native β-cyclodextrin through three reaction steps, such as monotosylation, azidation and reduction. All reaction steps were studied separately and optimized under continuous flow conditions. After the optimization, the reaction steps were coupled in a semi-continuous flow system, since a solvent exchange had to be performed after the tosylation. However, the azidation and the reduction step… Show more
In our work, serine-modified β-cyclodextrin (Ser-β-CD) was synthesized and Berberine hydrochloride (BBH)/Ser-β-CD inclusion complex (IC) was prepared by the freeze-drying method. It could be shown that BBH and Ser-β-CD can...
In our work, serine-modified β-cyclodextrin (Ser-β-CD) was synthesized and Berberine hydrochloride (BBH)/Ser-β-CD inclusion complex (IC) was prepared by the freeze-drying method. It could be shown that BBH and Ser-β-CD can...
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