Continuous Generation of Millimeter-Sized Glycine Crystals in Non-Seeded Millifluidic Slug Flow

Mou, Mingyao; Li, Huayu; Yang, Bing‐Shiou; Jiang, Mo

doi:10.3390/cryst9080412

Cited by 21 publications

(37 citation statements)

References 80 publications

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“…This can be achieved by simply extending the processing time; therefore, more slugs are generated. − However, as already mentioned, this type of scale-up is only suitable for a several times higher productivity. If the ordinary scale-up of a slug flow crystallizer is performed (larger dimensions of a system), the process dynamics can be severely affected. , A larger diameter can also cause the difficulty of splitting two phases into slugs . The scale-up of slug flow crystallizers can also have a negative effect on mixing in slugs, which has already been shown at the microchannel level …”

Section: From Batch To Continuous Processes: the Influence Of Operati...mentioning

confidence: 99%

“…If the ordinary scale-up of a slug flow crystallizer is performed (larger dimensions of a system), the process dynamics can be severely affected. 63,64 A larger diameter can also cause the difficulty of splitting two phases into slugs. 41 The scale-up of slug flow crystallizers can also have a negative effect on mixing in slugs, which has already been shown at the microchannel level.…”

Section: From Batch To Continuous Processes: the Influence Of Operati...mentioning

confidence: 99%

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Continuous Crystallization Processes in Pharmaceutical Manufacturing: A Review

Orehek

Teslić

Likozar

2020

Org. Process Res. Dev.

116

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This scientific paper presents an overview of continuous solution crystallization in the pharmaceutical industry. Since the specific knowledge spectrum of precipitation is very broad, topics covering the following were analyzed and assessed in detail: a comparison between batch and continuous crystallizers, their engineering advantages/disadvantages, the introduction of the solid form structuring to continuously oriented chemical production, and the usage of the online process analytical technology (PAT) methodologies in interacting functional systems. Furthermore, mechanistic multiscale modeling, whose understanding is of decisive importance for further control application development, was thoroughly discussed as well. The multiscale modeling section also includes the simulation of processes and the optimization of crystallizers. In the last section, model-based predictive control (MPC) is considered, which also covers the intensification approach methods in the field of crystal formation and the introduction of new, highly potential continuous systems, e.g. the coiled flow inverter (CFI) crystallizer, in industry and academia. In the mentioned main sections, individual theme-related articles are collected, discussed, and compared; therefore, a reader can get acquainted with pieces of research, their found results, which have been developed until now, and various emerging perspectives. With regard to the importance of crystallization in the pharmaceutical industry, a reader can already find literature on continuous crystallization. However, due to the growing tendency toward the synthesis of products with specific properties which cannot be achieved with conventional approaches, more attention has been paid in the present work to the establishment of continuous systems for the production of specific fine chemicals. In addition, continuous crystallization could also enable more efficient and "on-demand" production, modeling for optimization, MPC, and intensification approaches. A review of the literature classifying studies according to the choice of a continuous system and their description was omitted in this study, as such reviews are already available in the literature.

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Section: From Batch To Continuous Processes: the Influence Of Operati...mentioning

confidence: 99%

Section: From Batch To Continuous Processes: the Influence Of Operati...mentioning

confidence: 99%

Continuous Crystallization Processes in Pharmaceutical Manufacturing: A Review

Orehek

Teslić

Likozar

2020

Org. Process Res. Dev.

116

View full text Add to dashboard Cite

show abstract

“…Mou et al. studied the production of glycine crystals by using the slug‐flow tubular crystallization method without adding seed crystals 18. The results showed that the aspect ratio of the slug also affected the results of primary nucleation.…”

Section: Introductionmentioning

confidence: 99%

“…Besides, the slugflow crystallization method can usually be applied to obtain better crystal product quality in continuous-flow tubular crystallization [17]. Mou et al studied the production of glycine crystals by using the slug-flow tubular crystallization method without adding seed crystals [18]. The results showed that the aspect ratio of the slug also affected the results of primary Mingpu Yuan 1 Jingkang Wang 1,2 Xin Huang 1,2,3, * Ting Wang 1,2,3 Na Wang 1,2,3 Lina Zhou 1,2 Hongxun Hao [19].…”

Section: Introductionmentioning

confidence: 99%

Ultrasound‐Assisted Slug‐Flow Tubular Crystallization for Preparation of Fine Ibuprofen Crystals

et al. 2022

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Ibuprofen fine crystals prepared by commonly used methods have some problems such as low‐crystallinity product and uneven distributed particle size. An ultrasonic‐assisted tubular crystallization system was developed. The effects of tubular crystallization temperature, supersaturation, residence time, surfactant, and flow pattern on the crystal size distribution and average particle size were studied. It was found that ultrasound promotes nucleation and reduces crystal aggregation. Ibuprofen crystals with an average particle size of 6.23 μm were formed owing to the high degree of continuous supersaturation and promoted micromixing. Finally, a possible mechanism of enhancement of micromixing under ultrasonic and slug flow on tubular crystallization was proposed.

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“…This Special Issue collects six studies on different aspects of anti-solvent crystallization development, with a particular focus on pharmaceutical crystallization. In the first contribution, continuous crystallization of glycine was developed in slug flow crystallizer [1]. A crash cooling stage was introduced in the entry section to induce nucleation.…”

mentioning

confidence: 99%