Continuous Glucose Monitoring in the Subcutaneous Tissue over a 14-Day Sensor Wear Period

Abstract

The study shows that a 14-day sensor wear period is achievable. Moreover, sensors using "wired enzyme" technology showed excellent in vivo stability, with no significant sensitivity loss over the 14-day wear period.

Factory-Calibrated Continuous Glucose Sensors: The Science Behind the Technology

“…To our knowledge, no scientific studies have been published previously evaluating the feasibility of factory calibration besides the ones leading to FreeStyle Libre. [9][10][11][12][13] All calibration-related studies and publications were focused on understanding and improving the standard BG-based fingerstick calibration [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] or overcoming transient effects, such as lag and signal artifacts [31][32][33][34][35] that can impact calibration. This demonstrates the novelty of this alternative approach and also possibly the superiority of the chemistry used in FreeStyle Libre over other sensor systems.…”

“…39 Sensor stability for the FreeStyle Libre sensor over its 14-day use period has been demonstrated earlier. 10 The in vitro tests include an initial sensitivity test, where the sensor is exposed to glucose solutions with different glucose concentrations. From the sensor response, a sensitivity value can be calculated.…”

Flash Glucose Monitoring: The Future Is Here

“…Lowest cost of a CGM system (flash glucose monitoring) 11 No calibration needed 12 (I can't emphasize this enough as it is a big deal for most patients) First 14-day factory-calibrated flash glucose monitoring 11,12 Reliable and accurate data available on demand throughout its use 9 Similar (lower) MARD (mean absolute relative difference) throughout 14 days of use 11,13 The features that distinguish flash glucose monitoring from CGM include (1) no alerts or alarms. Many patients are fed up with the alarms from CGM systems (several of them ''false'') and get an ''alarm fatigue'' and thus have adopted flash glucose monitoring gladly 14 ; (2) the data are recorded continuously as with other CGMs; however, they are only available on demand for 14 days and can be downloaded; (3) the adoption of ambulatory glucose profile (AGP) in the downloaded data has been well validated in the literature, and both patients and providers can visualize the data in a simple and standardized way.…”

Accuracy of a flash glucose monitoring system in diabetic dogs

“…The mediator then passes the electrons to the electrode for measurement, this avoids using oxygen and thus the requirement for a limiting membrane on the sensor. 11,12 The detection limits of the sensor are between 20 and 500 mg/dL; however, the readings beyond this range are not recorded. The system starts working 1 hour from application (Fig 1).…”