Continuous glucose monitoring is more sensitive than HbA1c and fasting glucose in detecting dysglycaemia in a Spanish population without diabetes

Rodrı́guez-Segade, Santiago; Rodríguez, Juan Enrique Arias; Camiña, Félix; Fernández-Arean, Manuel; García-Ciudad, Vanessa; Pazos-Couselo, Marcos; García-López, José Manuel; Alonso-Sampedro, Manuela; González‐Quintela, Arturo

doi:10.1016/j.diabres.2018.05.026

Cited by 16 publications

(20 citation statements)

References 30 publications

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“…Data from healthy individuals without diabetes could help identify thresholds that signify impaired glycemic status in those at risk for diabetes and set the standard for CGM metrics that should be sought in the development of future pharmacologic agents and technologic improvements. [3][4][5][6][7][8][9] However, there are limited data on CGM-measured glucose concentrations in individuals without diabetes. Most studies of CGM profiles in healthy individuals without diabetes have had small sample sizes or used early generation CGM systems, which were less accurate than the current devices, and rarely explored important factors, such as meals and physical activity, that could impact glycemia.…”

Section: Introductionmentioning

confidence: 99%

Effect of Exercise and Meals on Continuous Glucose Monitor Data in Healthy Individuals Without Diabetes

DuBose

Sherr

et al. 2020

J Diabetes Sci Technol

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Objective: The aim of these analyses was to characterize the effect of exercise and meals on glucose concentrations in healthy individuals without diabetes. Methods: Healthy individuals without diabetes (age ≥6 years) with nonobese body mass index were enrolled at 12 centers within the T1D Exchange Clinic Network. Participants wore a blinded Dexcom G6 for up to ten days. Throughout this sensor wear, participants completed a daily log indicating times and type of any exercise and start times of meals and snacks. Results: A total of 153 participants (age 7-80 years) were included in the analyses. Exercise induced a mean change of −15 ± 18 mg/dL from baseline to nadir sensor glucose level. Mean nadir glucose concentration during nights following exercise days was 82 ± 11 mg/dL compared with 85 ± 11 mg/dL during nights following nonexercise days ( P = .05). Mean change from baseline to nadir sensor glucose level during aerobic exercise was −15 ± 18 and −9 ± 12 mg/dL for resistance exercise ( P = .25). Overnight nadir glucose during nights following aerobic and resistance exercise was 83 ± 12 and 76 ± 14 mg/dL, respectively ( P = .25). Overall mean peak postprandial glucose per participant increased from 93 ± 10 mg/dL premeal to 130 ± 13 mg/dL with an average time to peak glucose per participant of 97 ± 31 minutes. Consumption of alcohol on the day prior did not impact overnight mean or nadir glucose. Conclusion: The present analysis provides important data characterizing the effect of exercise and meals on glucose in healthy individuals without diabetes. These data provide a repository to which future therapies, whether pharmacologic or technologic, can be compared.

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Section: Introductionmentioning

confidence: 99%

Effect of Exercise and Meals on Continuous Glucose Monitor Data in Healthy Individuals Without Diabetes

DuBose

Sherr

et al. 2020

J Diabetes Sci Technol

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“…Knowledge of the impact of aging on glucose curves is essential for identifying those affected, determining the mechanisms behind the CGM is an accurate technology that provides more information than conventional measurement systems [14][15]. Although CGM is mainly used for individuals with diabetes, recent studies have shown that CGM is a useful, reliable, and accurate diagnostic tool for studying glycemic behavior in populations without diabetes [3,10]. Recent studies have shown the need for using other types of glycemic measurements, such as time in range, which is strongly associated with the risk of microvascular complications and should be an acceptable endpoint for clinical trials [16].…”

Section: Discussionmentioning

confidence: 99%

“…Current knowledge on normoglycemia is largely based on studies with populations without diabetes [17][18][4][5][6][7][8][9][10][11], in which the progression of glucose profiles has not been studied, resulting in a limited understanding of the real-life blood glucose patterns of healthy individuals. Determining how long normoglycemic individuals spend at different blood glucose levels in real-life conditions and the progression of those levels over time is a necessary step in establishing reference points for more detailed studies of altered glycemic states.…”

Section: Discussionmentioning

confidence: 99%

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Aging of glucose profiles in an adult population without diabetes

Pazos-Couselo

Portos-Regueiro

González-Rodríguez

et al. 2022

Diabetes Research and Clinical Practice

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“…Also, Rodriguez-Segade et al have shown that the use of CGM can better detect dysglycemia in persons without diabetes. 41 In one study, CGM was used to identify children at risk for T1D as well. 42 In these cases, short-term use or intermittent use of CGM can be meaningful and makes a good diagnostic tool.…”

Section: Possible Situations/indications For Intermittent Cgm Usagementioning

confidence: 99%

Intermittent Use of Continuous Glucose Monitoring: Expanding the Clinical Value of CGM

Ziegler¹,

Heinemann²,

Freckmann

et al. 2020

J Diabetes Sci Technol

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In addition to the continuous use, the intermittent use of continuous glucose monitoring (CGM) is an application of CGM, expanding the typical medical use cases. There are a variety of reasons and occasions that speak in favor of using CGM only for a limited time. To date, these circumstances have not been sufficiently discussed. In this article, we define discontinuous or intermittent CGM use, provide reasons for using it, and expand on the benefits and possibilities of using CGM on a temporary basis. We aim to draw attention to this important topic in the discussion of CGM use and give examples for a different method of CGM use. As well, we would like to foster the allocation of CGM to the right patient groups and indications, especially in cases of limited resources. From a global point of view, intermittent CGM use is more likely to occur than continuous use, primarily for economic reasons.

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Continuous glucose monitoring is more sensitive than HbA1c and fasting glucose in detecting dysglycaemia in a Spanish population without diabetes

Cited by 16 publications

References 30 publications

Effect of Exercise and Meals on Continuous Glucose Monitor Data in Healthy Individuals Without Diabetes

Effect of Exercise and Meals on Continuous Glucose Monitor Data in Healthy Individuals Without Diabetes

Aging of glucose profiles in an adult population without diabetes

Intermittent Use of Continuous Glucose Monitoring: Expanding the Clinical Value of CGM

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