1985
DOI: 10.1007/bf00280882
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Continuous infusion of glucose with model assessment: measurement of insulin resistance and ?-cell function in man

Abstract: Summary. Continuous infusion of glucose with model assessment (CIGMA) is a new method of assessing glucose tolerance, insulin resistance and r-cell function. It consists of a continuous glucose infusion 5mg glucose/kg ideal body weight per min for 60 min, with measurement of plasma glucose and insulin concentrations. These are similar to postprandial levels, change slowly, and depend on the dynamic interaction between the insulin produced and its effect on glucose turnover. The concentrations can be interprete… Show more

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Cited by 256 publications
(135 citation statements)
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“…Following basal sampling (±15, ±10, ±5 and 0 min), intravenous glucose was given at 0 min, then sampling followed at 3, 4, 5, 6, 8, 10, 12, 14, 16 and 19 min; at 20 min, insulin infusion was given, while sampling continued at 22,24,26,28,30,33,36,40,50,60,70,80, 100, 120, 140, 160, 180. Radioimmunoassay insulin and glucose were assayed on all samples.…”
Section: Methodsmentioning
confidence: 99%
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“…Following basal sampling (±15, ±10, ±5 and 0 min), intravenous glucose was given at 0 min, then sampling followed at 3, 4, 5, 6, 8, 10, 12, 14, 16 and 19 min; at 20 min, insulin infusion was given, while sampling continued at 22,24,26,28,30,33,36,40,50,60,70,80, 100, 120, 140, 160, 180. Radioimmunoassay insulin and glucose were assayed on all samples.…”
Section: Methodsmentioning
confidence: 99%
“…Assessment of the glucose and insulin concentrations in each person allows evaluation of the combination of deficient beta-cell function and impaired insulin sensitivity that are present. The simplest application is assessing the basal homeostasis by measuring fasting glucose and insulin concentrations with HOMA [24,27]. Since the basal concentrations of glucose and insulin are low and require precise and sensitive assays, the alternative method evaluates the near-steady state glucose/insulin concentrations after 2 h of a low dose, constant glucose infusion that induces plasma glucose and insulin concentrations similar to postprandial concentrations (modelled with CIGMA) [23, 25±27].…”
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confidence: 99%
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“…Parents of probands willing to undergo studies were studied with a continuous infusion of glucose (CIGMA) test [12]. This The fpg and apg concentrations after the 1-h CIGMA test (apg) are shown as Z scores, the deviation in SD from the mean of an age and BMI-matched normal population Fasting plasma glucose (fpg) and achieved plasma glucose (apg) are shown as Z age-and BMI-matched normal population scores, the deviation in SD from the mean of an consisted of a continuous intravenous infusion of 5 mg glucose.…”
Section: Methodsmentioning
confidence: 99%
“…Whole-body insulin sensitivity was calculated as proposed by Matsuda et al [24], where WBISI = 10,000/ √ (fasting glucose × fasting insulin) × (mean glucose × mean insulin during OGTT). The homeostatic model assessment of basal insulin resistance (HOMA-IR) was calculated using the formula: HOMA-IR = [fasting insulin (μU/ml) × fasting glucose (mmol/L)] / 22.5 [25,26]. Post-MMTT area under the curve (AUC) and incremental AUC for insulin and glucose were calculated using the trapezoidal method.…”
Section: Methodsmentioning
confidence: 99%