Continuous infusion of substance P into rat striatum relieves mechanical hypersensitivity caused by a partial sciatic nerve ligation via activation of striatal muscarinic receptors

Nakamura, Yoki; Fukushige, Ryo; Watanabe, Kohei; Kishida, Yukichi; Hisaoka-Nakashima, Kazue; Nakata, Yoshihiro; Morioka, Norimitsu

doi:10.1016/j.bbr.2020.112714

Cited by 2 publications

(1 citation statement)

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“…Nakamura et al found that the infusion of SP into the striatum inhibited PSL-evoked mechanical hypersensitivity, which was blocked by the co-infusion of NK1 receptor antagonist CP96345. Co-infusion of atropine, but not mecamylamine, also blocked the analgesic effect of SP infusion into the striatum, suggesting that activation of striatal muscarinic acetylcholine receptors through NK1 receptors could be a potential therapeutic method for neuropathic pain [101].…”

Section: Neural Plasticity In the Basal Ganglia During Neuropathic Pain And Its Modulationmentioning

confidence: 96%

Neural Plasticity in the Brain during Neuropathic Pain

2021

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Neuropathic pain is an intractable chronic pain, caused by damage to the somatosensory nervous system. To date, treatment for neuropathic pain has limited effects. For the development of efficient therapeutic methods, it is essential to fully understand the pathological mechanisms of neuropathic pain. Besides abnormal sensitization in the periphery and spinal cord, accumulating evidence suggests that neural plasticity in the brain is also critical for the development and maintenance of this pain. Recent technological advances in the measurement and manipulation of neuronal activity allow us to understand maladaptive plastic changes in the brain during neuropathic pain more precisely and modulate brain activity to reverse pain states at the preclinical and clinical levels. In this review paper, we discuss the current understanding of pathological neural plasticity in the four pain-related brain areas: the primary somatosensory cortex, the anterior cingulate cortex, the periaqueductal gray, and the basal ganglia. We also discuss potential treatments for neuropathic pain based on the modulation of neural plasticity in these brain areas.

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Section: Neural Plasticity In the Basal Ganglia During Neuropathic Pain And Its Modulationmentioning

confidence: 96%