Continuous infusion versus intermittent flushing: maintaining peripheral intravenous access in newborn infants

Stok, D; Wieringa, Jantien W

doi:10.1038/jp.2016.94

Cited by 11 publications

(15 citation statements)

References 11 publications

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“…In the current literature, we may perceive that comparisons of intermittent vs. infusion of, for example, an antibiotic delivery to humans has been published. 28,29 <0.001 NS <0.001 96 mg . kg -1 .min -1 <0.001 NS <0.001 192 mg .…”

Section: Discussionmentioning

confidence: 94%

Respiratory mechanics evaluation of mice submitted to intravenous methacholine: Bolus vs. continuous infusion

Vitorasso

Oliveira

Tavares-de-Lima

et al. 2020

Exp Biol Med (Maywood)

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The application of a bronchoconstrictor, usually Methacholine (MCh), in respiratory mechanics studies is usually accompanied by the assessment of respiratory mechanics in a dose–response curve. The MCh used in the dose–response curve can be inhaled (i.h.) and intravenous (i.v.) and there are studies comparing i.v. bolus and i.h. MCh in both mice and rats. However, MCh i.v. can be injected at short time interval (bolus) or in continuous infusion. This comparison is relevant since the way MCh is applied influences the mathematical model. We chose an aging process scenario to compare both protocols. This study aims to compare respiratory mechanics of 3-, 6-, and 10-month SAMR1 mice and how both administration methods (continuous infusion and bolus) impact respiratory mechanics evaluation. Both protocols were capable of assessing the difference among ages and doses in: peak or plateau; and area under the curve analysis. The respiratory mechanics parameters were Rn, G, and H (two-way analysis of variance: groups and doses with a P < 0.05 for all). Also, the infusion protocol presented a higher sensitivity to dose increment. In conclusion, both protocols were able to discriminate intragroup and intergroup differences. In the bolus protocol, the highest value of each curve dose may not correspond to the highest real value, and the loss of this point may be a problematic factor in the sample size. These factors are not present in the infusion protocol. Additionally, at this lineage and age screening, the infusion protocol appeared to be more sensitive to differences among ages when compared to the bolus protocol. Impact statement Respiratory mechanics studies are associated with fundamental research and translational studies; the present work thus investigates this particular matter. Our current research describes differences and similarities between two different ways of administrating a very prevalent bronchoconstrictor (methacholine) in an aging process scenario. The core issue of our work is related with troubles we find with the bolus protocol and the application of the mathematical model used to assess the respiratory mechanics. Our findings reveal the continuous infusion as an alternative to these problems and we hope to provide the proper foundations to a more reliable assessment in the respiratory field.

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Section: Discussionmentioning

confidence: 94%

Respiratory mechanics evaluation of mice submitted to intravenous methacholine: Bolus vs. continuous infusion

Vitorasso

Oliveira

Tavares-de-Lima

et al. 2020

Exp Biol Med (Maywood)

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“…4,5 One method is to run a continuous intravenous (IV) crystalloid infusion at a low rate "to keep the vein open" (TKO). 2,[6][7][8][9] An alternate option is the saline lock (SL) and intermittent flush method. 2,[6][7][8][9] There is a widespread perception that TKO prolongs the life of the PIV because a continuous infusion of fluid may decrease the risk of clot formation in the catheter.…”

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confidence: 99%

“…2,[6][7][8][9] An alternate option is the saline lock (SL) and intermittent flush method. 2,[6][7][8][9] There is a widespread perception that TKO prolongs the life of the PIV because a continuous infusion of fluid may decrease the risk of clot formation in the catheter. 7,10 However, evidence in the neonatal population has revealed that there is no significant difference in the duration of PIV patency between neonates with TKO and SL.…”

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confidence: 99%

“…2,[6][7][8][9] There is a widespread perception that TKO prolongs the life of the PIV because a continuous infusion of fluid may decrease the risk of clot formation in the catheter. 7,10 However, evidence in the neonatal population has revealed that there is no significant difference in the duration of PIV patency between neonates with TKO and SL. [7][8][9]11 To our knowledge, similar studies have not been performed in a pediatric population.…”

mentioning

confidence: 99%

“…7,10 However, evidence in the neonatal population has revealed that there is no significant difference in the duration of PIV patency between neonates with TKO and SL. [7][8][9]11 To our knowledge, similar studies have not been performed in a pediatric population.…”

mentioning

confidence: 99%

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Saline-Lock Versus Continuous Infusion: Maintaining Peripheral Intravenous Catheter Access in Children

Yeung

Miller

Ojha

et al. 2020

Hospital Pediatrics

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OBJECTIVES: In children, peripheral intravenous catheters (PIVs) are maintained by either a continuous infusion of fluid “to keep vein open” (TKO) or a saline lock (SL). There is a widespread perception that TKO prolongs PIV patency, but there is a lack of evidence for this. We hypothesized that there would be no significant difference in duration of PIV patency between TKO and SL. PATIENTS AND METHODS: This prospective, time-allocated study included patients from newborn to 17 years of age admitted to our pediatric ward. Patients enrolled in the first 3 months were assigned to TKO, and patients in the latter 3 months were assigned to SL. Primary outcome was duration of functional patency of the first PIV during the time of TKO or SL. Secondary outcomes included PIV-related complications and patient and caregiver satisfaction. RESULTS: Complete PIV data were available on 172 (n = 85 TKO, n = 87 SL) of 194 enrolled patients. The mean (SD) duration of PIV patency was 41.68 (41.71) hours in the TKO group and 44.05 (41.46) hours in the SL group, which was not significantly different (P = .71). There were no significant differences in complication rates or overall patient and caregiver satisfaction. One patient in the TKO group had their PIV removed because of risk of strangulation from tubing. CONCLUSION: There were no significant differences between TKO and SL in the duration of PIV patency, complication rates, and overall patient and caregiver satisfaction in our pediatric population. Overall, SL is a safe and reasonable alternative to TKO in maintaining PIV patency in children.

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Appropriateness of intravenous fluid prescriptions in hospitalised patients: a point prevalence study

Sneyers,

Nyssen,

Bulpa

et al. 2024

Int J Clin Pharm

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Continuous infusion versus intermittent flushing: maintaining peripheral intravenous access in newborn infants

Abstract: Intermittent flushing and continuous infusion provide a similar duration of PIVC patency; however, intermittent flushing is associated with fewer complications, lower cost and reduced time.

Cited by 11 publications

References 11 publications

Respiratory mechanics evaluation of mice submitted to intravenous methacholine: Bolus vs. continuous infusion

Respiratory mechanics evaluation of mice submitted to intravenous methacholine: Bolus vs. continuous infusion

Saline-Lock Versus Continuous Infusion: Maintaining Peripheral Intravenous Catheter Access in Children

Appropriateness of intravenous fluid prescriptions in hospitalised patients: a point prevalence study

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