Continuous IOP Fluctuation Recording in Normal Tension Glaucoma Patients

Pajic, Bojan; Pajic-Eggspuchler, Brigitte; Haefliger, Ivan O.

doi:10.3109/02713683.2011.608240

Cited by 55 publications

(47 citation statements)

References 28 publications

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“…6,7 This new approach was validated in vitro on cannulated enucleated eyes. 6 In a small number of studies, [8][9][10][11] this new device was used in humans with glaucoma.…”

mentioning

confidence: 99%

24-Hour Intraocular Pressure Rhythm in Young Healthy Subjects Evaluated With Continuous Monitoring Using a Contact Lens Sensor

et al. 2013

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IMPORTANCE This study evaluates a new device that has been proposed to continuously monitor intraocular pressure (IOP) over 24 hours.OBJECTIVE To evaluate 24-hour IOP rhythm reproducibility during repeated continuous 24-hour IOP monitoring with noncontact tonometry (NCT) and a contact lens sensor (CLS) in healthy participants. DESIGN, SETTING, AND PARTICIPANTSCross-sectional study of 12 young healthy volunteers at a referral center of chronobiology.INTERVENTIONS Participants were housed in a sleep laboratory and underwent four 24-hour sessions of IOP measurements over a 6-month period. After initial randomized attribution, the IOP of the first eye was continuously monitored using a CLS and the IOP of the fellow eye was measured hourly using NCT. Two sessions with NCT measurements in 1 eye and CLS measurements in the fellow eye, 1 session with CLS measurements in only 1 eye, and 1 session with NCT measurements in both eyes were performed. MAIN OUTCOMES AND MEASURESA nonlinear least squares, dual-harmonic regression analysis was used to model the 24-hour IOP rhythm. Comparison of acrophase, bathyphase, amplitude, midline estimating statistic of rhythm, IOP values, IOP changes, and agreement were evaluated in the 3 tonometry methods.RESULTS A significant nyctohemeral IOP rhythm was found in 31 of 36 sessions (86%) using NCT and in all sessions (100%) using CLS. Hourly awakening during NCT IOP measurements did not significantly change the mean phases of the 24-hour IOP pattern evaluated using CLS in the contralateral eye. Throughout the sessions, intraclass correlation coefficients of the CLS acrophase (0.6 [95% CI, 0.0 to 0.9]; P = .03), CLS bathyphase (0.7 [95% CI, 0.1 to 0.9]; P = .01), NCT amplitude (0.7 [95% CI, 0.1 to 0.9]; P = .01), and NCT midline estimating statistic of rhythm (0.9 [95% CI, 0.9 to 1.0]; P < .01) were significant. When performing NCT measurements in 1 eye and CLS measurements in the contralateral eye, the IOP change at each point normalized from the first measurement (9 AM) was not symmetric individually or within the population. CONCLUSIONS AND RELEVANCEThe CLS is an accurate and reproducible method to characterize the nyctohemeral IOP rhythm in healthy participants but does not allow for estimating the IOP value in millimeters of mercury corresponding to the relative variation of the electrical signal measured.

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“…6,7 This new approach was validated in vitro on cannulated enucleated eyes. 6 In a small number of studies, [8][9][10][11] this new device was used in humans with glaucoma.…”

mentioning

confidence: 99%

24-Hour Intraocular Pressure Rhythm in Young Healthy Subjects Evaluated With Continuous Monitoring Using a Contact Lens Sensor

et al. 2013

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“…45 Cerium oxide (CeO2) nanoparticles (nanoceria particles) have a big surface area to volume ratio which is very useful for scavenging reactive oxygen intermediates (free oxygen radicals). 46 Junping Chen et al observed prevention of light damage in rodent by intravitreal injection of nanoceria particles. It indicates promising role of this nanotechnology for the management of other oxidative damaged ophthalmic conditions like macular degeneration and diabetic retinopathy.…”

Section: Cataractmentioning

confidence: 99%

“…It indicates promising role of this nanotechnology for the management of other oxidative damaged ophthalmic conditions like macular degeneration and diabetic retinopathy. 46 Cetinel S et al suggested nanotechnology for the management of cataract. They opined that nonsurgical management of cataract can be done by promoting protein solubility and/or dissolving fibrillar aggregates.…”

Section: Cataractmentioning

confidence: 99%

Nanomedicine and its role in Ophthalmology

Akbani¹,

Bashir²

2014

J Cont Med A Dent

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In recent years, nanotechnology is rapidly emerging in the field of medicine. It has great potential in subfields of diagnosis, therapeutics and prophylaxis. It has created new and diverse avenues for development of new drug delivery system. In ophthalmology, due to unique and exposed nature of eyes nanotechnology has good prospects. In this article nanomedicine is review with special emphasis on ophthalmology.

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“…9 Patients with normal tension glaucoma 11 were monitored with the CLS off and on therapy. On the one hand these showed very unique profiles, on the other, three out of five patients…”

Section: First Applications In Humansmentioning

confidence: 99%

Contact Lens Sensor Triggerfish – What Do We Know?

Faschinger¹

2016

European Ophthalmic Review

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M ultiple measurements of the intraocular pressure (IOP) at different times during the day and at night provide information on the peak and trough values, and the number and magnitude of short-and long-term fluctuations. Goldmann applanation tonometry (GAT) is generally used only once or a few times during office hours. The ideal would be a safe, well-tolerated, and valid 24-hour measurement. The contact lens sensor Triggerfish ® (SENSIMED AG, Lausanne, Switzerland) is claimed to measure changes in corneal curvature induced by changes in IOP. After animal experiments, multiple studies in healthy and glaucoma patients were performed, in some cases revealing good correlation with tonometer values, in others poor or no correlation at all. The interpretation of the 24-hour profiles is not standardised, and there is no agreement upon definition of a fluctuation. Comparability between mmHg and an electrically measured value cannot be established. Despite the fact that safety and tolerability of the device are good, the absence of definitive validation of the results means that the product cannot yet be recommended for daily clinic or office use. This product is also no longer marketed as providing '24-hour IOP profile' or 'continuous monitoring of IOP fluctuation', but now rather as recording a '24-hour profile of ocular dimensional changes'. KeywordsIntraocular pressure, sensor contact lens, strain gauge, validity of "pressure" profile The review describes the current state of knowledge about this medical device, especially discussing the question whether an application in daily clinical or office use for diagnosing and therapeutic monitoring of glaucoma patients is necessary and/or recommended. Contact lens sensor Triggerfish -product descriptionThe theory published by Leonardi et al., was, that IOP could be measured indirectly by a strain gauge embedded in a contact lens. 3 The basis for this theory was that the corneal curvature in the limbal area (diameter of the strain gauge at 11.5 mm) changed with variation in IOP, and that this could be measured. Two circular strain gauges made from platinum-titanium (7 µm) and a loop antenna made from gold (30 µm) for data transfer and a microchip (50 µm) for wireless data management were embedded in a silicone contact lens (diameter 14.2 mm), through a complicated manufacturing process. For better patient tolerance it was coated with an oxygen plasma. Power is supplied by the recorder and an antenna which is stuck around the orbit. Measurements are taken at 5 minute intervals for 30 seconds, within these 30 seconds 10 times with 300 datasets.The gained data are transferred wirelessly via this antenna to a recorder which is worn around the waist. During the 24-hour measurement period spectacles with metal frames must be avoided, but all other normal daily activities should be performed and documented in a diary. This is with the exception of activities that include moisture and water (e.g. swimming, showering etc.) and

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Continuous IOP Fluctuation Recording in Normal Tension Glaucoma Patients

Abstract: Our data suggest that the continuous IOP fluctuation monitoring device is sensitive to individual IOP rhythms and to differences in such rhythms due to anti-glaucomatous drug therapy.

Cited by 55 publications

References 28 publications

24-Hour Intraocular Pressure Rhythm in Young Healthy Subjects Evaluated With Continuous Monitoring Using a Contact Lens Sensor

24-Hour Intraocular Pressure Rhythm in Young Healthy Subjects Evaluated With Continuous Monitoring Using a Contact Lens Sensor

Nanomedicine and its role in Ophthalmology

Contact Lens Sensor Triggerfish – What Do We Know?

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