Continuous low-level topical heat in the treatment of dysmenorrhea

Akin, Mark; Weingand, Kurt W.; Hengehold, D.; Goodale, Mary Beth; Hinkle, Robert T; Smith, Roger P.

doi:10.1016/s0029-7844(00)01163-7

Cited by 108 publications

(94 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One RCT has compared its use with the NSAID ibuprofen 20. The heat patch (39°C) used for 12 hours a day was found to be as effective as ibuprofen (400 mg three times a day) and more effective than placebo in reducing pain.…”

Section: How Is It Treated?mentioning

confidence: 99%

Diagnosis and management of dysmenorrhoea

Proctor

Farquhar

2006

BMJ

428

351

View full text Add to dashboard Cite

Section: How Is It Treated?mentioning

confidence: 99%

Diagnosis and management of dysmenorrhoea

Proctor

Farquhar

2006

BMJ

428

351

View full text Add to dashboard Cite

“…Naproxen and ibuprofen are widely believed to be the empirical choices in the gynecological field, especially for dysmenorrhea 7,8,9,10,11. However, our own experience found their effectiveness in treating CPP, caused by pelvic floor muscle pain, not satisfactory.…”

Section: Discussionmentioning

confidence: 81%

“…Naproxen or ibuprofen was generally used and studied as the first choice for dysmenorrhea 9,10,11. Meanwhile, it is customary to prescribe both medicines for pelvic floor muscle pain.…”

Section: Introductionmentioning

confidence: 99%

Concentration of Non-Steroidal Anti-Inflammatory Drugs in the Pelvic Floor Muscles: An Experimental Comparative Rat Model

Chin

Changchien²,

Lin³

et al. 2014

Yonsei Med J

View full text Add to dashboard Cite

PurposeThe aim of this study is to explore non-steroid anti-inflammation drugs (NSAIDs) potency for pelvic floor muscle pain by measuring local concentration in a rat model.Materials and MethodsWe used nine NSAIDs, including nabumetone, naproxen, ibuprofen, meloxicam, piroxicam, diclofenac potassium, etodolac, indomethacin, and sulindac, and 9 groups of female Wister rats. Each group of rats was fed with one kind of NSAID (2 mg/mL) for three consecutive days. Thereafter, one mL of blood and one gram of pelvic floor muscle were taken to measure drug pharmacokinetics, including partition coefficient, lipophilicity, elimination of half-life (T1/2) and muscle/plasma converting ratio (Css, muscle/Css, plasma).ResultsDiclofenac potassium had the lowest T1/2 and the highest mean Css, muscle/Css, plasma (1.9 hours and 0.85±0.53, respectively). The mean Css, muscle/Css, plasma of sulindac, naproxen and ibuprofen were lower than other experimental NSAIDs.ConclusionDiclofenac potassium had the highest disposition in pelvic floor muscle in a rat model. The finding implies that diclofenac potassium might be the choice for pain relief in pelvic muscle.

show abstract

“…Both results were comparable. 20 The second RCT also compared four treatments: abdominal heat wrap (heated to 40°C for 8 hours from the first morning after the start of menses); unheated abdominal wrap (for same time period); high dose paracetamol (1000 mg four times a day); and placebo. The heated wrap significantly reduced pain after 8 hours of treatment compared with paracetamol (P=0.015).…”

Section: Topical Heatmentioning

confidence: 99%