Continuous measurement of oxygen consumption in fetal sheep

Block, Barry S.; Parer, Julian T.; Court, D J; Llanos, Aníbal J.

doi:10.1016/s0002-9378(84)80148-9

Cited by 4 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Severe fetal hypoxemia with acidemia depresses cardiac output. 31 In the present study this cannot be excluded although the placental vascular endothelial growth factor expression revealed no increase after LPS injection. In human fetuses with severe placental insufficiency and increased vascular resistance, a shift in the fetal cardiac output toward the left ventricle has been shown.…”

Section: Discussioncontrasting

confidence: 60%

Mechanism of Acute Fetal Cardiovascular Depression after Maternal Inflammatory Challenge in Mouse

Rounioja

Räsänen

Ojaniemi

et al. 2005

The American Journal of Pathology

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 60%

Mechanism of Acute Fetal Cardiovascular Depression after Maternal Inflammatory Challenge in Mouse

Rounioja

Räsänen

Ojaniemi

et al. 2005

The American Journal of Pathology

View full text Add to dashboard Cite

show abstract

“…Myometrial contractures are characterized by low-amplitude epochs of myometrial contractility that last at least 3 min. Contractures induce a fall in fetal arterial PO 2 (22,23,29,31,49), a decrease in uterine blood flow (28,42), and a decrease in fetal activity and O 2 uptake (5,28). Contractures also compress the fetus (31).…”

mentioning

confidence: 99%

Increased myometrial contracture frequency at 96–140 days accelerates fetal cardiovascular maturation

Shinozuka

Yen

Nathanielsz

2000

American Journal of Physiology-Heart and Circulatory Physiology

View full text Add to dashboard Cite

Fetal cardiovascular responses to an altered intrauterine environment of increased myometrial contractures induced by oxytocin (OT) pulses to the ewe over the final 50 days of gestation were studied in chronically instrumented sheep. Ewes received saline (Cntl) or long-term OT treatment (LTOT, 600 microU x kg(-1) x min(-1) in 5-min pulses every 20 min) from 96 days gestational age. Fetal baroreflex responses to sodium nitroprusside (SNP) and phenylephrine (PE) were studied at 133 days gestation. OT increased contractures in LTOT ewes. Fetal blood pressure (FBP) was higher, and fetal heart rate (FHR) and slope of daily change in FBP and FHR were lower in LTOT fetuses. Fetal SNP-induced hypotension resulted in a narrow R-R interval variation range in LTOT fetuses; Cntl fetuses showed early breakdown in compensation. Baroreflex response slope during PE-induced fetal hypertension was lower in LTOT than in Cntl fetuses. Although the cortisol-to-ACTH ratio was lower in LTOT fetuses, fetal plasma ACTH and cortisol changes were similar in control and LTOT fetuses. We hypothesize that contracture-induced alterations in the intrauterine environment accelerate fetal cardiovascular development through mild hypoxemia, repetitive fetal pituitary-adrenal stimulation, and/or physical stimulation.

show abstract

Fetal oxygenation and Doppler ultrasonography of cardiovascular hemodynamics in a chronic near-term sheep model

Mäkikallio¹,

Erkinaro

Niemi³

et al. 2006

American Journal of Obstetrics and Gynecology

View full text Add to dashboard Cite

Continuous measurement of oxygen consumption in fetal sheep

Cited by 4 publications

References 8 publications

Mechanism of Acute Fetal Cardiovascular Depression after Maternal Inflammatory Challenge in Mouse

Mechanism of Acute Fetal Cardiovascular Depression after Maternal Inflammatory Challenge in Mouse

Increased myometrial contracture frequency at 96–140 days accelerates fetal cardiovascular maturation

Fetal oxygenation and Doppler ultrasonography of cardiovascular hemodynamics in a chronic near-term sheep model

Contact Info

Product

Resources

About