Continuous Non Invasive Monitoring of Human Brain by Near Infrared Spectroscopy

Ferrari, Marco; Giannini, I; Sideri, G; Zanette, E.

doi:10.1007/978-1-4684-3291-6_88

Cited by 106 publications

(52 citation statements)

References 16 publications

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“…In 1985, Ferrari et al 4 published the first description of the application of cerebral monitoring using NIRS, and in 1993, the first commercially available NIRS device was marketed by Somanetics (INVOS Ò 3100). Since this initial introduction to the clinical environment, the use of NIRS has become widespread.…”

Section: Introduction To the Technologymentioning

confidence: 99%

Near-Infrared Spectroscopy in the Monitoring of Adult Traumatic Brain Injury: A Review

Davies

Clancy

et al. 2015

Journal of Neurotrauma

132

101

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Cerebral near-infrared spectroscopy (NIRS) has long represented an exciting prospect for the noninvasive monitoring of cerebral tissue oxygenation and perfusion in the context of traumatic brain injury (TBI), although uncertainty still exists regarding the reliability of this technology specifically within this field. We have undertaken a review of the existing literature relating to the application of NIRS within TBI. We discuss current ''state-of-the-art'' NIRS monitoring, provide a brief background of the technology, and discuss the evidence regarding the ability of NIRS to substitute for established invasive monitoring in TBI.

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Section: Introduction To the Technologymentioning

confidence: 99%

Near-Infrared Spectroscopy in the Monitoring of Adult Traumatic Brain Injury: A Review

Davies

Clancy

et al. 2015

Journal of Neurotrauma

132

101

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“…14,15 It was a pleasant surprise to find Marco Ferrari at the ISOTT meeting where he presented a significant paper. 16 Several other groups, including the London one of Dawood Parker and David Delpy, also visited to learn about the new technique but they did not publish until later.…”

mentioning

confidence: 97%

Discovery of the Near-Infrared Window into the Body and the Early Development of Near-Infrared Spectroscopy

̈bsis-vanderVliet

1999

J. Biomed. Opt.

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Extension of optical monitoring of intact tissues from the visible and ultraviolet to the near-infrared (NIR) range (700-1300 nm) was first undertaken in 1977 for the purpose of monitoring the redox behavior of Cytochrome c oxidase (cyt c ox) in vivo. Soon it became evident that the much greater NIR translucency of skin and bone made it possible to reach brain and muscle tissue without surgical intervention. The presence of hemoglobin absorption led to complications forcing the construction of algorithms to separate the signals of the two molecular entities. It was also realized, however, that the hemoglobin signals provide information regarding the source of oxygen in the tissue, while the cyt c ox signals indicate the intracellular availability of oxygen for oxidative phosphorylation. This ability of recognizing the source/sink relationship greatly enhances the value of NIR spectrophotometry (NIRS) for research and clinical purposes. © 1999 Society of Photo-Optical Instrumentation Engineers.

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“…Most optical imaging thus far uses visible and/or near infrared (NIR) light between 400 and 1,000 nm, which can be detected with inexpensive silicon-based sensors. In this wavelength region, oxygenated and deoxygenated hemoglobin are the primary physiologically active optical absorbers, and the functional status of tissue can be measured based on their relative concentrations (5)(6)(7)(8).…”

mentioning

confidence: 99%

Using the shortwave infrared to image middle ear pathologies

Carr

Valdez

Bruns

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Visualizing structures deep inside opaque biological tissues is one of the central challenges in biomedical imaging. Optical imaging with visible light provides high resolution and sensitivity; however, scattering and absorption of light by tissue limits the imaging depth to superficial features. Imaging with shortwave infrared light (SWIR, 1–2 μm) shares many advantages of visible imaging, but light scattering in tissue is reduced, providing sufficient optical penetration depth to noninvasively interrogate subsurface tissue features. However, the clinical potential of this approach has been largely unexplored because suitable detectors, until recently, have been either unavailable or cost prohibitive. Here, taking advantage of newly available detector technology, we demonstrate the potential of SWIR light to improve diagnostics through the development of a medical otoscope for determining middle ear pathologies. We show that SWIR otoscopy has the potential to provide valuable diagnostic information complementary to that provided by visible pneumotoscopy. We show that in healthy adult human ears, deeper tissue penetration of SWIR light allows better visualization of middle ear structures through the tympanic membrane, including the ossicular chain, promontory, round window niche, and chorda tympani. In addition, we investigate the potential for detection of middle ear fluid, which has significant implications for diagnosing otitis media, the overdiagnosis of which is a primary factor in increased antibiotic resistance. Middle ear fluid shows strong light absorption between 1,400 and 1,550 nm, enabling straightforward fluid detection in a model using the SWIR otoscope. Moreover, our device is easily translatable to the clinic, as the ergonomics, visual output, and operation are similar to a conventional otoscope.

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Continuous Non Invasive Monitoring of Human Brain by Near Infrared Spectroscopy

Cited by 106 publications

References 16 publications

Near-Infrared Spectroscopy in the Monitoring of Adult Traumatic Brain Injury: A Review

Near-Infrared Spectroscopy in the Monitoring of Adult Traumatic Brain Injury: A Review

Discovery of the Near-Infrared Window into the Body and the Early Development of Near-Infrared Spectroscopy

Using the shortwave infrared to image middle ear pathologies

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