Fused SiO2 has been used as a new noncrystalline host for the fabrication of two types of neodymium-doped room-temperature lasers, one of which operates at 1.06-μm and the other at 1.08-μm wavelength. The lasers have the geometry of clad optical fibers, with active cores as small as 15-μm diameter by 1-cm length. They are end pumped at 0.590 and 0.5145 μm with a pulsed dye laser and an argon ion laser, respectively. Thresholds as low as 1–2 mW of absorbed pump power in a 40-μm-diam core have been obtained, and eventual pumping with high-radiance semiconductor optical sources appears feasible.