Continuous Positive Airway Pressure Therapy Reduces Oxidative Stress Markers and Blood Pressure in Sleep Apnea–Hypopnea Syndrome Patients

Murri, Mora; García-Delgado, R.; Alcázar-Ramírez, José D.; Rota, Luis Fernández de; Fernández-Ramos, Ana; Cardona, Fernando; Tinahones, Francisco J.

doi:10.1007/s12011-011-8969-1

Cited by 16 publications

(13 citation statements)

References 26 publications

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“…OSA is an independent risk factor in obesity for increased oxidative stress state as shown by diminishing of some oxidative stress-related markers after CPAP therapy [3,7,41]. …”

Section: Discussionmentioning

confidence: 99%

Biochemical oxidative stress-related markers in patients with obstructive sleep apnea

et al. 2011

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SummaryBackgroundObstructive sleep apnea (OSA) is a condition contributing to oxidative stress. The aim of this study was to ascertain if there is any connection between OSA and novel oxidative stress-related markers. Matrix metalloproteinases 2 and 9 (MMP-2, MMP-9), high sensitive C-reactive protein (hsCRP), pregnancy-associated plasma protein-A (PAPP-A), soluble receptors for advanced glycation end-products (sRAGE), zinc (Zn) and copper (Cu) were measured. Further biochemical markers were evaluated.Material/MethodsFifty-one men suspected for OSA indicated for night polygraphy were included. Apnea/hypopnea index (AHI), oxygen desaturation index (ODI), mean blood hemoglobin oxygen saturation (SpO2) and time of blood hemoglobin oxygen saturation below 90% (SpO2 <90%) were measured. Morning venous blood samples were taken.ResultsFor body mass index (BMI) we found strong positive correlation with levels of Cu, MMP-9, hsCRP and fibrinogen, and negative correlation with sRAGE. Concerning ventilation parameters, we found positive correlation of ODI and SpO2 <90% with markers MMP-9 and hsCRP. sRAGE level correlated with AHI and ODI negatively. SpO2 correlated negatively with Cu, MMP-9, hsCRP and fibrinogen. There was no correlation between ventilation parameters and markers MMP-2, PAPP-A and Zn. Compared to severity of OSA, there was significant difference in levels of hsCRP and Cu between patients with AHI ≤5 and AHI ≥30 independent of BMI.ConclusionsMMP-9, hsCRP, sRAGE and Cu seem to be strong predictors of oxidative stress in OSA patients. The strong correlation between oxidative stress-related markers and OSA is elucidated by connection of these to BMI, which is probably a primary condition of oxidative stress, but OSA is an additive condition.

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“…OSA is an independent risk factor in obesity for increased oxidative stress state as shown by diminishing of some oxidative stress-related markers after CPAP therapy [3,7,41]. …”

Section: Discussionmentioning

confidence: 99%

Biochemical oxidative stress-related markers in patients with obstructive sleep apnea

et al. 2011

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“…62,63 CPAP reduces systemic biomarkers of oxidative stress but has shown only modest and inconsistent improvement in improving glucose control in patients with MetS. [64][65][66] In contrast, this therapy has been effective in reducing blood pressure in patients with resistant hypertension and OSA. 67 In summary, there is ample evidence suggesting that OSA can induce or exacerbate most, if not all, of the MetS components.…”

Section: Mets and Osamentioning

confidence: 99%

Metabolic Syndrome and the Lung

Baffi

Wood

Winnica

et al. 2016

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182

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A link between metabolic syndrome (MetS) and lung diseases has been observed in several cross-sectional and longitudinal studies. This syndrome has been identified as an independent risk factor for worsening respiratory symptoms, greater lung function impairment, pulmonary hypertension, and asthma. This review will discuss several potential mechanisms to explain these associations, including dietary factors and the effect of adiposity and fat-induced inflammation on the lungs, and the role of other comorbidities that frequently coexist with MetS, such as OSA and obesity. In contrast to the well-known association between asthma and obesity, the recognition that MetS affects the lung is relatively new. Although some controversy remains as to whether MetS is a unique disease entity, its individual components have independently been associated with changes in pulmonary function or lung disease. There is, however, uncertainty as to the relative contribution that each metabolic factor has in adversely affecting the respiratory system; also, it is unclear how much of the MetS-related lung effects occur independently of obesity. In spite of these epidemiological limitations, the proposed mechanistic pathways strongly suggest that this association is likely to be causal. Given the wide prevalence of MetS in the general population, it is imperative that we continue to further understand how this metabolic disorder impacts the lung and how to prevent its complications.

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“…or enhance NO production; NO can bind to superoxide to produce toxic peroxynitrite.) , 2008;Alzoghaibi & Bahammam, 2011;Carpagnano et al, 2003;de Lima et al, 2010;Murri et al, 2009Murri et al, , 2011. ↓ Cell energy → Glutamate excitotoxicity → OS Impaired cell energy may promote glutamate excitotoxicity, leading to more OS (Nicholls, 2009).…”

Section: Branch Of Model Nr Relationshipmentioning

confidence: 99%

Coenzyme Q10 Benefits Symptoms in Gulf War Veterans: Results of a Randomized Double-Blind Study

et al. 2014

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We sought to assess whether coenzyme Q10 (CoQ10) benefits the chronic multisymptom problems that affect one-quarter to one-third of 1990-1 Gulf War veterans, using a randomized, double-blind, placebo-controlled study. Participants were 46 veterans meeting Kansas and Centers for Disease Control criteria for Gulf War illness. Intervention was PharmaNord (Denmark) CoQ10 100 mg per day (Q100), 300 mg per day (Q300), or an identical-appearing placebo for 3.5 ± 0.5 months. General self-rated health (GSRH), the primary outcome, differed across randomization arms at baseline, and sex significantly predicted GSRH change, compelling adjustment for baseline GSRH and prompting sex-stratified analysis. GSRH showed no significant benefit in the combined-sex sample. Among males (85% of participants), Q100 significantly benefited GSRH versus placebo and versus Q300, providing emphasis on Q100. Physical function (summary performance score, SPS) improved on Q100 versus placebo. A rise in CoQ10 approached significance as a predictor of improvement in GSRH and significantly predicted SPS improvement. Among 20 symptoms each present in half or more of the enrolled veterans, direction-of-difference on Q100 versus placebo was favorable for all except sleep problems; sign test 19:1, p=0.00004) with several symptoms individually significant. Significance for these symptoms despite the small sample underscores large effect sizes, and an apparent relation of key outcomes to CoQ10 change increases prospects for causality. In conclusion, Q100 conferred benefit to physical function and symptoms in veterans with Gulf War illness. Examination in a larger sample is warranted, and findings from this study can inform the conduct of a larger trial.

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Continuous Positive Airway Pressure Therapy Reduces Oxidative Stress Markers and Blood Pressure in Sleep Apnea–Hypopnea Syndrome Patients

Cited by 16 publications

References 26 publications

Biochemical oxidative stress-related markers in patients with obstructive sleep apnea

Biochemical oxidative stress-related markers in patients with obstructive sleep apnea

Metabolic Syndrome and the Lung

Coenzyme Q10 Benefits Symptoms in Gulf War Veterans: Results of a Randomized Double-Blind Study

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