Continuous Positive Airway Pressure Treatment Does not Reduce Uric Acid Levels in OSA Women

Campos‐Rodríguez, Francisco; Reyes-Núñez, Nuria; Queipo-Corona, Carlos; Sánchez‐Armengol, Ángeles; Jurado-Gámez, Bernabé; Cordero-Guevara, José; Troncoso, María Fernanda; Abad-Fernández, Araceli; Caballero-Rodriguez, Julian; Martin-Romero, Mercedes; Encabo-Motiño, Ana; Sacristan-Bou, Lirios; Navarro-Esteva, Javier; Somoza‐González, María; Masa, Juan F.; Sánchez-Quiroga, M-Ángeles; Jara-Chinarro, Beatriz; Orosa-Bertol, Belen; Martínez‐García, Miguel Ángel; Santos-Morano, Juan; Gonzalez-Martinez, Mónica; Carmona-Bernal, Carmen; Feu-Collado, Nuria; Rodriguez-Rodriguez, Paula; Cano-Pumarega, Irene; Alonso-Alvarez, Maria L.; Galvez-Martinez, Beatriz; Reina-Marfil, Nuria; Selma, Maria J.; Quintana-Hidalgo, Lucia L.; Llunell-Casanovas, Antonia; Corral, Jaime; Sedano, Andrea Crespo

doi:10.1016/j.arbr.2018.09.016

Cited by 2 publications

(3 citation statements)

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“…Among the 24 studies, 19 studies were subsequently excluded (see detail in Figure 1). Finally, 5 studies [8, 16–18] were included in the meta-analysis. Two of them were RCT [16, 18]; three were observational study.…”

Section: Resultsmentioning

confidence: 99%

“…A total of five articles including six cohorts with 270 patients met the inclusion criteria and were included in this meta-analysis. Two of them were randomized clinical trials (RCTs) [16, 18]; the other studies were observational [8, 17, 19]. One study [19] reported results separately for the good compliance group (mean CPAP use ≥4 h/night) and the poor compliance group (mean CPAP use <4 h/night).…”

Section: Resultsmentioning

confidence: 99%

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Does Continuous Positive Airway Pressure Therapy in Patients with Obstructive Sleep Apnea Improves Uric Acid? A Meta-Analysis

Chen

Lin

Chen

et al. 2019

Oxidative Medicine and Cellular Longevity

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Purpose. The efficacy of obstructive sleep apnea (OSA) therapy with continuous positive airway pressure (CPAP) on uric acid (UA) yielded conflicting results. This meta-analysis was performed to assess whether OSA treatment with CPAP could reduce UA levels. Methods. The Web of Science, Cochrane Library, Embase, and PubMed were searched before March 2019. Information of patients, study design, and pre- and post-CPAP treatment of UA was utilized for analysis. The overall effects were analyzed via the standardized mean difference (SMD) with a 95% confidence interval (CI). Five studies were obtained and the meta-analysis was performed using Stata 12.0 and Review Manager 5.2. Results. A total of 5 studies with 6 cohorts (2 RCT and 3 observational studies) involving 270 patients were pooled into meta-analysis. There was no change of UA levels before and after CPAP treatment in OSA patients (SMD=‐0.20, 95% CI: -0.78 to 0.37, Z=0.69, p=0.49). Subgroup analysis showed that the outcomes were not affected by age of patients, gender distribution, baseline body mass index, daily duration, duration of CPAP treatment, sample size, and study design. Conclusions. This meta-analysis revealed that CPAP treatment has no effect on UA in OSA patients. Further well-designed, large-scale randomized controlled trials are required to address this issue.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Does Continuous Positive Airway Pressure Therapy in Patients with Obstructive Sleep Apnea Improves Uric Acid? A Meta-Analysis

Chen

Lin

Chen

et al. 2019

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…Approximately, 10–17% of men and 3–9% of women suffer from OSA [ 1 ]. Common symptoms reported by patients, such as snoring, lethargy, nonrestorative sleep, and excessive daytime sleepiness, as well as systematic diseases like hypertension [ 2 ], coronary artery disease, and stroke [ 3 , 4 ], are linked to untreated OSA.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of an oropharyngeal obstruction evaluation score

Peng,

Chen,

Yang

et al. 2024

Sleep Breath

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Objective To identify standard clinical parameters that can predict the presence and severity of obstructive sleep apnea. Subjects and methods Adult patients with habitual snoring completed comprehensive polysomnography and anthropometric measurements, including sex, age, body mass index (BMI), neck circumference, tonsil size grading, modified Mallampati score, and nasofibroscopy-assisted Muller’s maneuver (NMM). Spearman’s correlation coefficient was used to screen the significant variables. Stepwise multiple linear regression analysis was then conducted to identify the independent variables. receiver operating characteristic (ROC) curve analysis was used to quantify the predictability of the formed oropharyngeal obstruction scoring system. Results A total of 163 adults (127 men) were enrolled in the study. Tonsil size grading, modified Mallampati score, and NMM grading maneuver were predictive of OSA and incorporated into a scoring system. This score ranged between 3 and 12, and threshold values of ≥ 8 and ≥ 9 seemed to be appropriate to identify patients at an increased risk of at least mild (AHI ≥ 5/h; AUROC = 0.935, 95%CI = 0.900–0.970, P < 0.001) and severe OSA (AHI ≥ 30/h; AUROC = 0.939, 95%CI = 0.899–0.969, P < 0.001), respectively. Conclusion This study established an evaluation score for assessing the degree of oropharhygeal obstruction. The findings of the study suggest that the score may help identify patients at risk of oropharyngeal-related OSA who should have a full sleep evaluation.

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Continuous Positive Airway Pressure Treatment Does not Reduce Uric Acid Levels in OSA Women

Cited by 2 publications

References 20 publications

Does Continuous Positive Airway Pressure Therapy in Patients with Obstructive Sleep Apnea Improves Uric Acid? A Meta-Analysis

Does Continuous Positive Airway Pressure Therapy in Patients with Obstructive Sleep Apnea Improves Uric Acid? A Meta-Analysis

Development and validation of an oropharyngeal obstruction evaluation score

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