Continuous positive pressure ventilation combined with pulmonary surfactant in the treatment of neonatal respiratory distress syndrome

Abstract

Objective: To analyze the clinical effect of nasal continuous positive airway pressure (CPAP) combined with pulmonary surfactant in the treatment of neonatal respiratory distress syndrome (NRDS).
 Methods: Eighty-two NRDS patients who received treatment from August 2017 to June 2019 in our hospital were selected and divided into a control group and an observation group using random number table, 41 in each group. The control group was treated with CPAP, and the observation group was treated with pulmonary surfactant injection besides CPAP. The therapeutic effect, blood gas index, mechanical ventilation parameters and occurrence of complications were compared between the two groups.
 Results: The total response rate of the observation group was 90.24%, which was significantly higher than 70.73% of the control group, and the difference had statistical significance (P<0.05). After treatment, the improvement of blood gas indexes of the observation group was better than that of the control group. The hospitalization time and duration of oxygen treatment of the observation group were shorter than those of the control group, and the hospitalization cost was higher than the control group (P<0.05). The difference of incidence of complications between the two groups was statistically significant (P<0.05).
 Conclusion: Endotracheal injection of pulmonary surfactant combined with CPAP in the treatment of NRDS can enhance the efficacy, promote the recovery of blood gas index, and reduce the parameters of mechanical ventilation and the incidence of complications, which is conducive to improving the respiratory function of the newborn. The therapy is worth application in the treatment of NRDS patients.
 doi: https://doi.org/10.12669/pjms.36.4.1963
 How to cite this:Miao J, Xie H, Zhang Y, Guo X, Cui M. Continuous positive pressure ventilation combined with pulmonary surfactant in the treatment of neonatal respiratory distress syndrome. Pak J Med Sci. 2020;36(4):---------. doi: https://doi.org/10.12669/pjms.36.4.1963
 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Effect of Nasal Continuous Airway Pressure With and Without Surfactant Administration for the Treatment of Respiratory Distress Syndrome in Preterm Neonates

“…Non-invasive ventilation includes several ventilation techniques. NCPAP and early surfactant therapy should be initiated at delivery in preterm infants with RDS [16]. This study compared the effectiveness of NCPAP with and without surfactant in preterm neonates with RDS.…”

“…After obtaining ethical approval (IRB-UOL-/1815-V/2022) from the Institutional Review Board Committee of the University of Lahore, Lahore Pakistan, an open-labeled randomized controlled trial study was conducted according to CONSORT guidelines on 100 neonates from the Paediatrics Department, Neonatal Intensive Care Unit, the University of Lahore Teaching Hospital, Lahore. The sample size was calculated using the effectiveness of treatment in CPAP with surfactant group (90.24%) and CPAP without surfactant group (70.73%) [16] with a level of significance of 5%, 80% power of test, and 20% expected dropout rate.…”

“…A study on 82 neonates with RDS found that CPAP with surfactant administration significantly improved treatment response rates and hospital stays, reducing complications and enhancing respiratory function. This therapy is beneficial for patients with RDS, as it encourages recovery and reduces mechanical ventilation requirements [16].…”