Continuous Powder Mixing

Osorio, Juan G.; Vanarase, Aditya U.; Romañach, Rodolfo J.; Muzzio, Fernando J.

doi:10.1002/9781118682692.ch6

Cited by 18 publications

(8 citation statements)

References 39 publications

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“…Continuous blending has a number of advantages over the traditional batchwise method, similar to the case of the earlier described technologies in previous sections . Steady state operation can be reached within a few minutes, in which process control is much more accurate, improving quality . The equipment used for process development can be used for production, eliminating the difficulty of scale-up and reducing the footprint.…”

Section: Recent Progress In Continuous Pharmaceutical Technologiesmentioning

confidence: 97%

“…182 Steady state operation can be reached within a few minutes, in which process control is much more accurate, improving quality. 184 The equipment used for process development can be used for production, eliminating the difficulty of scale-up and reducing the footprint. The continuous operation makes the integration possible with the following continuous tableting step.…”

Section: Integrated Continuous Crystallization and Filtrationmentioning

confidence: 99%

“…Bladed, ribbon or ribbon-bladed impellers can be applied, which direct the flow in axial direction (Figure 5). 184 Vanarase et al published a study about an experimental investigation of the mixing performance and flow behavior in a continuous blender using a pharmaceutical mixture. 186 The impeller rotation rate was found to be the most important process parameter affecting the mixing performance, and the blade configuration also had an effect on powder homogeneity.…”

Section: Integrated Continuous Crystallization and Filtrationmentioning

confidence: 99%

“…tablets with acceptable drug content uniformity. Continuous blending has long been known in the mentioned industries; however, in the pharmaceutical industry, batch mixers are applied in the vast majority of cases to date . The rising of continuous pharmaceutical manufacturing in recent years gave a new push to continuous blending as well.…”

Section: Recent Progress In Continuous Pharmaceutical Technologiesmentioning

confidence: 99%

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Integrated Continuous Pharmaceutical Technologies—A Review

Domokos

Nagy

Szilágyi

et al. 2021

Org. Process Res. Dev.

103

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Innovation in the pharmaceutical industry has been limited for a long time to the research and development of new active compounds; meanwhile, the structure of the production, dominated by batchwise technologies, has not changed to date. As has already been demonstrated in several other industrial sectors, continuous manufacturing (CM) has many advantages over batch processes. Faster, cheaper, and more flexible production can be developed with a significantly higher level of quality assurance. In the recent years the main regulatory agencies recognized the need for a change in drug production and started to promote continuous technologies and encourage pharmaceutical companies to develop and adapt such processes. As a result, by today extensive research was conducted in the various fields of pharmaceutical technologies from drug substance to drug product manufacturing. Many publications deal with synthetic steps carried out in flow reactors and crystallizations implemented in a continuous manner, and on the formulation side continuous filtration, drying, granulation, and blending have all been studied to a lesser or greater extent. Moreover, besides the modification of these traditional processes to continuous operation, novel, intrinsically continuous technologies are being studied as well. In order to entirely exploit the advantages of CM, the mainly separately developed processes need to be integrated to form end-to-end systems from the raw materials to the final dosage forms. However, even the integration of two technological steps is a challenging task. The development of end-to-end systems requires deep process understanding and a holistic approach toward process development and optimization. The aim of this work is to give insight into the state-of-the-art and new directions in integrated continuous pharmaceutical technologies by critically reviewing the recent literature of the broad field.

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Section: Recent Progress In Continuous Pharmaceutical Technologiesmentioning

confidence: 97%

Section: Integrated Continuous Crystallization and Filtrationmentioning

confidence: 99%

Section: Integrated Continuous Crystallization and Filtrationmentioning

confidence: 99%

Section: Recent Progress In Continuous Pharmaceutical Technologiesmentioning

confidence: 99%

See 2 more Smart Citations

Integrated Continuous Pharmaceutical Technologies—A Review

Domokos

Nagy

Szilágyi

et al. 2021

Org. Process Res. Dev.

103

View full text Add to dashboard Cite

show abstract

“…Application of vibratory machines for the agitation of bulk materials makes it possible to increase performance efficiency of the machine, reduce its energy consumption, and of the mixer), which are typically by an order of magnitude lower than the forces of dry internal friction [12,13]. In addition, during mixing it is necessary to overcome the forces of gravity trying to bring particles of the material down, which leads to stratification.…”

Section: Introductionmentioning

confidence: 99%