Continuous Processing in the Pharmaceutical Industry

Plumb, K.

doi:10.1205/cherd.04359

Cited by 394 publications

(252 citation statements)

References 0 publications

Supporting

Mentioning

250

Contrasting

Unclassified

Order By: Relevance

“…Synthesis of most fine and specialty chemical-particularly pharmaceuticals-is typically carried out in a liquid phase and batch operation, despite the fact that batch processes cause a number of problems, especially with scaling up and producing within homogeneous processing conditions [1]. Flow reactors have many advantages over batch reactors: continuous production, better process control, easier automation, and reduced operation costs.…”

Section: Introductionmentioning

confidence: 99%

Continuous-Flow Monolithic Silica Microreactors with Arenesulphonic Acid Groups: Structure–Catalytic Activity Relationships

et al. 2017

View full text Add to dashboard Cite

Abstract:The performance of monolithic silica microreactors activated with sulphonic acid groups and a packed bed reactor with Amberlyst 15 resin were compared in the esterification of acetic acid with n-butanol. The monolithic microreactors were made of single silica rods with complex pore architecture, differing in the size of mesopores, and in particular, flow-through macropores which significantly affected the flow characteristic of the continuous system. The highest ester productivity of 105.2 mol·mol H +−1 ·h −1 was achieved in microreactor M1 with the largest porosity, characterized by a total pore volume of 4 cm 3 ·g −1 , mesopores with 20 nm diameter, and large flow-through macropores 30-50 µm in size. The strong impact of the permeability of the monoliths on a reaction kinetics was shown.

show abstract

Section: Introductionmentioning

confidence: 99%

Continuous-Flow Monolithic Silica Microreactors with Arenesulphonic Acid Groups: Structure–Catalytic Activity Relationships

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Moreover, variability in product quality is caused through insufficient process control; hence, advanced control strategies can be employed to ensure consistent product quality [5,[7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Process Modification of Pharmaceutical Tablet Manufacturing Operations: An Eco-Efficiency Approach

et al. 2018

View full text Add to dashboard Cite

Abstract:A process improvement in a tablet manufacturing process within a pharmaceutical industry was carried out based on an eco-efficiency approach. As it is one of the most energy consuming processes in the production line, the tablet manufacturing process was considered. It has the highest production volume with a complicated and long manufacturing product life cycle. Data were collected on energy inputs and emissions data for the stages of powder direct mixing, particle size reduction, and tableting. A straightforward approach was then used to analyze environmental impacts in terms of GHG emissions. Non-added value steps were removed from the product life cycle process, which has led to significant time and cost savings, as well as to a reduction in the emission. Annual economic savings have been achieved, a time reduction of approximately 71% was attained, and the reduction in GHG emissions and energy cost were 73.2%. The g CO 2 eq per tablet reduction has been calculated within the process improvement to be 2.06 g CO 2 eq per tablet instead of 7.71 g CO 2 eq per tablet.

show abstract

“…However, rising market competition and the need to reduce manufacturing costs are driving the future of pharmaceutical and fine chemical industries towards continuous processes, which have potential for improvements in product quality, through on-line process monitoring and control, and reduced equipment footprint, energy and labor costs [4][5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

Mathematical Modeling, Design, and Optimization of a Multisegment Multiaddition Plug-Flow Crystallizer for Antisolvent Crystallizations

Benyahia

Nagy

et al. 2015

Org. Process Res. Dev.

View full text Add to dashboard Cite

Just Accepted "Just Accepted" manuscripts have been peer-reviewed and accepted for publication. They are posted online prior to technical editing, formatting for publication and author proofing. The American Chemical Society provides "Just Accepted" as a free service to the research community to expedite the dissemination of scientific material as soon as possible after acceptance. "Just Accepted" manuscripts appear in full in PDF format accompanied by an HTML abstract. "Just Accepted" manuscripts have been fully peer reviewed, but should not be considered the official version of record. They are accessible to all readers and citable by the Digital Object Identifier (DOI®). "Just Accepted" is an optional service offered to authors. Therefore, the "Just Accepted" Web site may not include all articles that will be published in the journal. After a manuscript is technically edited and formatted, it will be removed from the "Just Accepted" Web site and published as an ASAP article. Note that technical editing may introduce minor changes to the manuscript text and/or graphics which could affect content, and all legal disclaimers and ethical guidelines that apply to the journal pertain. ACS cannot be held responsible for errors or consequences arising from the use of information contained in these "Just Accepted" manuscripts. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 2 TABLE OF CONTENTS 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 The configuration in which anti-solvent could be added at a variety of different locations along the tube length and at optimal flow rates was able to outperform previous designs in the literature which considered equally-spaced anti-solvent additions. The use of dynamic models to detect problems during startup of an MSMA-PFC was also highlighted.

show abstract

Continuous Processing in the Pharmaceutical Industry

Cited by 394 publications

References 0 publications

Continuous-Flow Monolithic Silica Microreactors with Arenesulphonic Acid Groups: Structure–Catalytic Activity Relationships

Continuous-Flow Monolithic Silica Microreactors with Arenesulphonic Acid Groups: Structure–Catalytic Activity Relationships

Process Modification of Pharmaceutical Tablet Manufacturing Operations: An Eco-Efficiency Approach

Mathematical Modeling, Design, and Optimization of a Multisegment Multiaddition Plug-Flow Crystallizer for Antisolvent Crystallizations

Contact Info

Product

Resources

About