Continuous production of amines directly from alkenes via cyclodextrin-mediated hydroaminomethylation using only water as the solvent

Abstract

Aqueous hydroaminomethylation (HAM) is an atom economic route for the efficient production of amines in one reaction step, starting from basic chemicals like alkenes. Herein we present the first successful...

Stable and Continuous Production of Amines via Reductive Amination in a Green Switchable Solvent System with Efficient Water Removal

“…19 If the interplay of reaction and a recycling concept is to be evaluated, it is advisable to conduct the investigations in a miniplant to study the separation efficiency in a continuous and long-time operation. 27,28 The miniplant consists of a continuous stirred tank reactor (B1, CSTR), a decanter for phase separation after reaction (B2), a buffer tank (B3) for the catalyst phase, and a membrane module (M1) (Figure 3). The substrates diethylamine and undecanal are continuously fed into the CSTR.…”

Hydroaminomethylation of methyl 10-undecenoate with integrated catalyst recycling via a thermomorphic multiphase system for the continuous production of renewable amines

“…Due to this problem, a phase mediator is oen needed. For example, co-solvents, such as nbutanol, 12 or phase transfer agents and surfactants like cyclodextrins [13][14][15] or hexadecyltrimethylammonium chloride (CTAC) 16 were already investigated in the HAM. Another approach to avoid these mass transfer limitations are so-called thermomorphic multiphase systems (TMS).…”