Continuous Processing in Pharmaceutical Manufacturing 2014
DOI: 10.1002/9783527673681.ch12
|View full text |Cite
|
Sign up to set email alerts
|

Continuous Production of Bacteriophages

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

0
5
0

Year Published

2017
2017
2024
2024

Publication Types

Select...
6
1

Relationship

1
6

Authors

Journals

citations
Cited by 7 publications
(5 citation statements)
references
References 149 publications
0
5
0
Order By: Relevance
“…Therefore, we assumed that also term “d” is small enough to be neglected. Equation then simplifies into Equation (Podgornik et al., ).λ=δ·C(b·eL·λ1)…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Therefore, we assumed that also term “d” is small enough to be neglected. Equation then simplifies into Equation (Podgornik et al., ).λ=δ·C(b·eL·λ1)…”
Section: Introductionmentioning
confidence: 99%
“…However, pharmaceutical manufacturing is nowadays changing the trend from a batch to continuous production (Jungbauer, 2013;Lee et al, 2015). Thus, we can speculate that phage production for bacteriophage therapy will follow the same path in the future and new knowledge in this field is required (Podgornik, Janež, Smrekar, & Peterka, 2014). Chemostat is a bioreactor to which fresh medium is continuously added, while spent medium containing microorganisms, unconsumed nutrients and metabolic end products is removed at the same rate in order to keep the working volume constant (Novick & Szilard, 1950).…”
mentioning
confidence: 99%
“…Synchronization of the host in the first stage before infection led to improvements in the specific productivity of phages in the second stage while maintaining the volumetric productivity. Podgornik et al (2014) explained the process of bacteriophage multiplication and implemented it in their continuous production in bioreactors. Moreover, this work showed the mathematical model of production of bacteriophages in the continuous regime.…”
Section: Batch Systemmentioning
confidence: 99%
“…Large scale phage propagations are commonly performed in bioreactor systems involving bacterial growth followed by phage infection within the same vessel 20 . This type of batch operation is considered inexpensive, simple, and robust, with short runs capable of yielding titers between 10 10 to 10 16 PFU/mL 3 , 21 , 37 . However, the long downtime periods in-between production runs that are necessary for proper cleaning and sterilization are significant disadvantages 3 .…”
Section: Introductionmentioning
confidence: 99%