Continuous Production of Tablet Granulations in a Fluidized Bed I

Scott, Morton W.; Lieberman, Herbert A.; Rankell, Albert S.; Battista, Joseph V.

doi:10.1002/jps.2600530315

Cited by 37 publications

(7 citation statements)

References 7 publications

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“…Furthermore, powder bed would expand with increased inlet airflow rate, thereby increasing interparticle distances. Under these production conditions, the particles had possessed high kinetic energies would show increased in attritive tendencies (38). The negative effect of atomizing air pressure was in agreement with previously reported results (16,17,39).…”

Section: Influence Of Design Variables Of Second Doe On Granule Size supporting

confidence: 91%

“…Both inlet airflow rate and atomizing air pressure had negative effects on MMD and percentage of lumps. Increased rate of evaporation was expected with increasing air flow rate due to improved heat transfer coefficient (30,38). Therefore, the potential for good wetting and agglomeration of the particles would be impaired.…”

Section: Influence Of Design Variables Of Second Doe On Granule Size mentioning

confidence: 99%

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Investigation on Side-Spray Fluidized Bed Granulation with Swirling Airflow

2012

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Abstract. Top-spray fluidized bed granulation with axial fluidization airflow from the bottom of the granulator is well-established in the pharmaceutical industry. The application of swirling airflow for fluidized bed granulation was more recently introduced. This study examined the effects of various process parameters on the granules produced by side-spray fluidized bed with swirling airflow using the central composite and Box-Behnken design of experiment. Influence of the amount of binder solution, spray rate, and distance between spray nozzle and powder bed were initially studied to establish operationally viable values for these parameters. This was followed by an in-depth investigation on the effects of inlet airflow rate, atomizing air pressure and distance between spray nozzle and powder bed on granule properties. It was found that the amount of binder solution had a positive correlation with granule size and percentage of lumps but a negative correlation with size distribution and Hausner ratio of the granules. Binder solution spray rate was also found to affect the granules size. High drug content uniformity was observed in all the batches of granules produced. Both inlet airflow rate and atomizing air pressure were found to correlate negatively with granule size and percentage of lumps but correlate positively with the size distribution of the granule produced. Percentage of fines was found to be significantly affected by inlet airflow rate. Distance between spray nozzle and powder bed generally affected the percentage of lumps.

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Section: Influence Of Design Variables Of Second Doe On Granule Size supporting

confidence: 91%

Section: Influence Of Design Variables Of Second Doe On Granule Size mentioning

confidence: 99%

Investigation on Side-Spray Fluidized Bed Granulation with Swirling Airflow

2012

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“…Advances in air suspension and other fluidized bed technology. such as that recently noted by Scott et al (3,4). suggest that a method like one described here may be made continuous.…”

Section: Discussionmentioning

confidence: 55%

New Preparative Technique for Effervescent Products

Coletta

Kennon

1964

Journal of Pharmaceutical Sciences

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“…So far, there are several models of granulation mechanisms employed for explaining the formation of granules [1,[7][8][9][10][11][12].…”

Section: Effect On the Granule Morphologymentioning

confidence: 99%

“…The granulation process applying fluidized bed technology is recognized as the fluidized bed granulation. Scott et al [11] is among the first pioneer studying and developing a fluidized bed granulator using modification of a fluidized bed dryer [11]. They reported that in this granulation technique there are many parameters affecting properties of granules produced.…”

Section: Introductionmentioning

confidence: 99%