Continuous production of uniform chitosan beads as hemostatic dressings by a facile flow injection method

Li, Boxuan; Wang, Juan; Gui, Qin

doi:10.1039/d0tb01462a

Cited by 29 publications

(20 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, CS membranes are used in membrane techniques, also for metal sorption and water purification [14]. Chitosan, as a low-toxicity hydrophilic biopoly-mer with additional composite materials, offers a new class of materials for bioimaging applications, for example, as fluorescent beads or a membrane [20][21][22][23]. Polymer composites consist of at least two phases (continuous and dispersed) with distinct interfaces [24].…”

Section: Introductionmentioning

confidence: 99%

Incorporation of Fluorescent Fluorinated Methacrylate Nano-Sized Particles into Chitosan Matrix Formed as a Membranes or Beads

et al. 2022

View full text Add to dashboard Cite

Fluorescent particles are of particular interest as probes and active agents for biomedical, pharmaceutical, and food applications. Here, we present two strategies for incorporation of core-shell acrylic fluorescent nanoparticles (NPs) with Rhodamine B (RhB) as a dye into a chitosan (CS) matrix. We selected two variants of NPsRhB immobilisation in a CS membrane and biopolymeric CS beads. Modification of the method for production of the biopolymer cover/transporter of nanoparticles allowed two series of hydrogels loaded with nanoparticles to be obtained with a similar concentration of the aqueous solution of the nanoparticles. Microscopic analysis showed that the NPs were nonuniformly distributed in millimetre-sized CS beads, as well as membranes, but the fluorescence signal was strong. The composition of CS layers loaded with nanoparticles (CS/NPsRhB) showed water vapour barrier properties, characterised by the contact angle of 71.8°. Finally, we incorporated NPsRhBCS beads into a gelatine matrix to check their stability. The results confirmed good stability of the NPsRhBCS complex system, and no dye leakage was observed from the beads and the membranes. The proposed complex system demonstrated promising potential for further use in bioimaging and, thus, for the development of advanced diagnostic tools.

show abstract

Section: Introductionmentioning

confidence: 99%

Incorporation of Fluorescent Fluorinated Methacrylate Nano-Sized Particles into Chitosan Matrix Formed as a Membranes or Beads

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Positively charged chitosan molecules can disrupt negatively charged bacterial cell walls via electrostatic forces [ 29 ]. In general, the application of chitosan as an additive in the porous collagen matrix can positively improve both healing and antibacterial properties of the material since, above all, chitosan was reported to have mucoadhesive and hemostatic properties [ 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Synergistic Effect of Chitosan and Selenium Nanoparticles on Biodegradation and Antibacterial Properties of Collagenous Scaffolds Designed for Infected Burn Wounds

et al. 2020

View full text Add to dashboard Cite

A highly porous scaffold is a desirable outcome in the field of tissue engineering. The porous structure mediates water-retaining properties that ensure good nutrient transportation as well as creates a suitable environment for cells. In this study, porous antibacterial collagenous scaffolds containing chitosan and selenium nanoparticles (SeNPs) as antibacterial agents were studied. The addition of antibacterial agents increased the application potential of the material for infected and chronic wounds. The morphology, swelling, biodegradation, and antibacterial activity of collagen-based scaffolds were characterized systematically to investigate the overall impact of the antibacterial additives. The additives visibly influenced the morphology, water-retaining properties as well as the stability of the materials in the presence of collagenase enzymes. Even at concentrations as low as 5 ppm of SeNPs, modified polymeric scaffolds showed considerable inhibition activity towards Gram-positive bacterial strains such as Staphylococcus aureus and methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis in a dose-dependent manner.

show abstract

“…[43] The mucoadhesive property allows nanoparticles to markedly prolong the retention time in ocular tissues and impede drug clearance. [44] For example, DexaSite has shown success in clinical trials for treating postoperative inflammation and pain following ocular surgery (NCT03192137), which is mainly attributed to the addition of chitosan to achieve greater viscosity for effective dexamethasone delivery. To improve the time-consuming and laborious nature of the polysaccharide fabrication process, functional drug-free and shear flow-driven layer-by-layer (SF-LbL)-assembled nanofilms consisting of chitosan and heparin were successfully constructed for corneal modification and defective wound healing.…”

Section: Natural Polymersmentioning

confidence: 99%

Ocular Nanomedicine

et al. 2022

View full text Add to dashboard Cite

Intrinsic shortcomings associated with conventional therapeutic strategies often compromise treatment efficacy in clinical ophthalmology, prompting the rapid development of versatile alternatives for satisfactory diagnostics and therapeutics. Given advances in material science, nanochemistry, and nanobiotechnology, a broad spectrum of functional nanosystems has been explored to satisfy the extensive requirements of ophthalmologic applications. In the present review, the recent progress in nanosystems, both conventional and emerging nanomaterials in ophthalmology from state-of-the-art studies, are comprehensively examined and the role of their fundamental physicochemical properties in bioavailability, tissue penetration, biodistribution, and elimination after interacting with the ophthalmologic microenvironment emphasized. Furthermore, along with the development of surface engineering of nanomaterials, emerging theranostic methodologies are promoted as potential alternatives for multipurpose ocular applications, such as emerging biomimetic ophthalmology (e.g., smart electrochemical eye), thus provoking a holistic review of "ocular nanomedicine." By affording insight into challenges encountered by ocular nanomedicine and further highlighting the direction of future studies, this review provides an incentive for enriching ocular nanomedicine-based fundamental research and future clinical translation.

show abstract

Continuous production of uniform chitosan beads as hemostatic dressings by a facile flow injection method

Abstract: In this work, we developed a facile flow injection method to fabricate chitosan beads of uniform size in a continuous manner and assessed their properties as hemostatic dressing. Chitosan was...

Cited by 29 publications

References 36 publications

Incorporation of Fluorescent Fluorinated Methacrylate Nano-Sized Particles into Chitosan Matrix Formed as a Membranes or Beads

Incorporation of Fluorescent Fluorinated Methacrylate Nano-Sized Particles into Chitosan Matrix Formed as a Membranes or Beads

Synergistic Effect of Chitosan and Selenium Nanoparticles on Biodegradation and Antibacterial Properties of Collagenous Scaffolds Designed for Infected Burn Wounds

Ocular Nanomedicine

Contact Info

Product

Resources

About