Continuous Recording of Uteroplacental Blood Volume in the Human

Lippert, T. H.; Cloeren, Stella; Fridrich, R; Hinselmann, M.

doi:10.3109/00016347309158300

Cited by 15 publications

(6 citation statements)

References 4 publications

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“…The reasons for these discrepancies, apart from discernible uterine contractions, could not be determined. The placenta continuously undergoes blood volume and flow changes similar to the hemometakinesia or 'borrowing-lending' phenomenon described by De Bakey et al [3], as could be demonstrated by a new technic for measur ing the hemodynamics of the placenta [11]. Thus, the observed variations in clearance half-time can be explained and the value of single-measure ments for the placenta are of limited value.…”

Section: Discussionmentioning

confidence: 93%

Critical Assessment of the Xenon Washout Technic for Measurement of Placental Blood Flow

Th¹,

Friedrich²,

P³

et al. 1973

Gynecol Obstet Invest

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The xenon washout technic has been assessed as a method for measuring placental blood flow in humans. In the first group of 20 patients, the ¹³³Xe injection was made blindly into the placenta; in the second group of 20 patients, a new technic was employed to ensure injection into the vascular (intervillous) space. The results have been calculated as clearance half-times, in seconds. Both groups gave widely differing results. After comparing the clearance half-times for ¹³³Xe with those for ^99mTc-albumin, it was concluded that with intervillous ¹³³Xe injections, a true xenon washout effect does not occur. Thus, calculations for blood flow in ml/g tissue/unit time are not considered valid. Further, the method cannot be recommended as a test for the action of drugs on placental blood flow. Firstly, under the influence of spontaneous placental pressure variations, single measurements are of limited value. Secondly, as blood examinations have shown the needle puncture itself may damage fetal vessels, permitting possibly dangerous fetomaternal transfusion.

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Section: Discussionmentioning

confidence: 93%

Critical Assessment of the Xenon Washout Technic for Measurement of Placental Blood Flow

Th¹,

Friedrich²,

P³

et al. 1973

Gynecol Obstet Invest

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“…Intravasal hypovolemia, a decreased cardiac output and diminished uteroplacental flow (BLEKTA et al 1970, FRIEDBERG et d. 1967, SMITH 1970, ASSALI 1954, BERGER et al 1963, LIPPERT et al 1973) are some of the cardiovascular alterations in toxemia in spite of the clinical signs of edema and overhydration.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Pre‐eclampsia and Eclampsia as a Hypoperfusion Syndrome

Söder

GRENROTH

Norée

et al. 1975

Acta Anaesthesiol Scand

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A therapeutical program in pre-eclampsia and eclampsia is presented. The results in 10 patients suggest that the same basic program as is used in the hypoperfusion syndrome can be used in pre-eclampsia and eclampsia:Chlorpromazin to combat vasoconstriction and dilate the vascular bed. Plasma expanders, plasma, albumin and glucose with electrolytes to fill up Buffers to combat acidosis, oxygen to combat hypoxemia, hypertonic Manni-Furosemide to force diuresis.the dilated vascular bed and restore the tissue perfusion.to1 to mobilize edema.

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“…Dies war bereits aus experimentellen Untersuchungen bei Menschen unter Verwendung radioaktiver Substanzen bekannt[14]. Dies war bereits aus experimentellen Untersuchungen bei Menschen unter Verwendung radioaktiver Substanzen bekannt[14].…”

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Die nichtinvasive Darstellung und Quantifizierung der plazentaren Durchblutung im Verlauf der Schwangerschaft, bei intrauteriner Wachstumsrestriktion und intrauterinem Fruchttod

Jörn¹,

Gerke²,

Kahn³

et al. 2004

Geburtshilfe Frauenheilkd

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ZusammenfassungFragestellung: Der Power-Doppler ist aufgrund seiner Sensitivität in der Lage, die Mikrozirkulation detaillierter zu untersuchen. Ein von uns interdisziplinär entwickeltes Programm zur weitergehenden Analyse der Power-Doppler-Originalsequenzen ist in der Lage, nichtinvasiv die parenchymatöse Durchblutung der Plazenta darzustellen und zu quantifizieren. Methodik: Untersucht wurden Patientinnen während des 1. Trimenons (n = 8) und des 3. Trimenons (Gestationsalter bei der Geburt > 37. Woche; Geburtsgewicht > 3000 g; vaginale Entbindung oder primäre Sectio ohne Zeichen des ¹fetal distressª; n = 15), Fälle mit hochgradiger intrauteriner Wachstumsretardierung (Gestationsalter bei der Geburt < 35. Woche; Geburtsgewicht < 1500 g; Sectio mit Zeichen des ¹fetal distressª; n = 5) und intrauterinem Fruchttod (n = 3), während der Wehentätigkeit (n = 3) und vor und nach betamimetischer Behandlung zur intravenösen Tokolyse (n = 3). Zusätzlich wurde der Einfluss der maternalen Atmung auf die Plazentadurchblutung (n = 20) analysiert. Die störungsfrei aufgenommenen Power-Doppler-Originalsequenzen wurden auf ein digitales Videogerät und dann auf eine Linux-Workstation überspielt. Intensitäten und Anzahl der Farbpixel erscheinen in einem 3D-Diagramm für eine beliebige Anzahl von Bildern. AbstractPurpose: Amplitude-coded Doppler sonography (ªpower Dopplerº) has improved sensitivity and is able to detect blood flow from the microcirculation. Using a programme that was developed interdisciplinarily by Aachen University, we are able to display and quantify colour coded pictures of parenchymatous placental blood flow for further analysis. This technique was evaluated for clinical application. Methods: We examined patients during the 1st trimester (n = 8) and the 3rd trimester (gestational age > 37 wks; birth weight > 3000 g; caesarean delivery because of fetal distress; n = 15), cases complicated by severe IUGR (gestational age < 35 wks; birth weight < 1500 g; vaginal or caesarean delivery without signs of fetal distress; n = 5) and IUD (n = 3), during labour (n = 3) and before and after intravenous medication with betamimetic tocolytic drugs (n = 3). In addition, we investigated the effect of maternal breathing on placental blood flow (n = 20). Artefact-free sequences of colour coded images were stored on a digital video recorder and transferred to a Linux workstation. Frequencies of intensities of colour pixels were displayed using 3 D-diagrams. Results: The common diagram showed a larger peak of lower intensities (pre-and postcapillary blood vessels/intervillous space) and a smaller peak of greater intensities (fetal stem villi blood

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Continuous Recording of Uteroplacental Blood Volume in the Human

Cited by 15 publications

References 4 publications

Critical Assessment of the Xenon Washout Technic for Measurement of Placental Blood Flow

Critical Assessment of the Xenon Washout Technic for Measurement of Placental Blood Flow

Treatment of Pre‐eclampsia and Eclampsia as a Hypoperfusion Syndrome

Die nichtinvasive Darstellung und Quantifizierung der plazentaren Durchblutung im Verlauf der Schwangerschaft, bei intrauteriner Wachstumsrestriktion und intrauterinem Fruchttod

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