Continuous release of mefloquine featured in electrospun fiber membranes alleviates epidural fibrosis and aids in sensory neurological function after lumbar laminectomy

Yue, Zhihao; Hu, Bo; Chen, Zhe; Zheng, Genjiang; Wang, Yunhao; Yang, Chen; Cao, Peng; Wu, Xiaodong; Liang, Lijun; Zang, Fazhi; Wang, Jianxi; Li, Jing; Zhang, Tao; Wu, Jinglei; Chen, Huajiang

doi:10.1016/j.mtbio.2022.100469

Cited by 3 publications

(3 citation statements)

References 69 publications

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“…especially after microdiscectomy operation, epidural fibrosis rates and methods to reduce these numbers can be found in a large number of articles for example, in the experimental study conducted by Keskin et al [21] in rats, it was noticed that the use of berberine in vivo significantly reduced epidural fibrosis. Similarly, Dayanır et al [22] addressed the same issue through ozone, while many different research teams have studied the effects of systemic or local use of different molecules and pharmaceutical agents on epidural fibrosis [23,24]. In our series, when comparing flavum-preserving surgery with standard surgery, no comparison has been made radiologically regarding the development of epidural fibrosis.…”

Section: Discussionmentioning

confidence: 90%

Current Approaches, Significance and Prognostic Impact of Lumbar Ligament Flavum Preserving Surgeries

ALPERGİN,

ZAİMOĞLU,

ÖZPİŞKİN

et al. 2024

Pam Tıp Derg

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Objectives: The aim of this study is to evaluate the use of flavum-preserving surgeries in lumbar disc herniation surgery, compare their clinical outcomes with standard microdiscectomy techniques, and demonstrate the transflaval microdiscectomy technique. Material and Methods: Between 2020 and 2023, a total of 48 patients who underwent transflaval microdiscectomy and 48 patients who underwent standard microdiscectomy at a single center were included in the study. Epidemiologic characteristics of the groups were described, and preoperative and postoperative visual analoge scale scores for leg pain (LPVAS) and back pain (BPVAS) were retrospectively analyzed. Results: There is no significant difference between the groups in preoperative mean LPVAS scores (p=0,474) and there is no significant difference between the groups in postoperative mean LPVAS scores (p=0,598). There is no significant difference between the groups in preoperative mean BPVAS scores (p=0,608). However there is a significant difference between the groups in postoperative mean BPVAS scores (p

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Section: Discussionmentioning

confidence: 90%

Current Approaches, Significance and Prognostic Impact of Lumbar Ligament Flavum Preserving Surgeries

ALPERGİN,

ZAİMOĞLU,

ÖZPİŞKİN

et al. 2024

Pam Tıp Derg

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“…However, in situations involving chronic pain, glial cells like microglia, astrocytes, and satellite glial cells undergo morphological and functional changes which contribute to increased pain sensitivity [ 26 , 27 ]. An additional significant factor to consider is the formation of scar tissue [ 28 ]. After spinal surgery, fibroblasts and other cells involved in wound healing can produce extracellular matrix proteins, leading to the formation of scar tissue [ 29 ].…”

Section: Molecular Mechanisms Underlying the Pathology Of The Psps-t1...mentioning

confidence: 99%

Failed Back Surgery Syndrome: No Longer a Surgeon’s Defeat—A Narrative Review

Miękisiak

2023

Medicina

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The introduction of the term Persistent Spinal Pain Syndrome (PSPS-T1/2), replacing the older term Failed Back Surgery Syndrome (FBSS), has significantly influenced our approach to diagnosing and treating post-surgical spinal pain. This comprehensive review discusses this change and its effects on patient care. Various diagnostic methods are employed to elucidate the underlying causes of back pain, and this information is critical in guiding treatment decisions. The management of PSPS-T1/2 involves both causative treatments, which directly address the root cause of pain, and symptomatic treatments, which focus on managing the symptoms of pain and improving overall function. The importance of a multidisciplinary and holistic approach is emphasized in the treatment of PSPS-T1/2. This approach is patient-centered and treatment plans are customized to individual patient needs and circumstances. The review concludes with a reflection on the impact of the new PSPS nomenclature on the perception and management of post-surgical spinal pain.

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“…7 Specifically, electrospinning has emerged as a powerful technique to produce fibrous structures, and it is a simple and efficient method for preparing long-acting formulations. [8][9][10] It applies a high voltage to spray charged threads of the drug-loaded polymer solution and results in nano/microfibers on solvent evaporation. 11 Recently, various electrospinning drug delivery systems have been prepared for the local delivery of therapeutic agents owing to the ease of drug encapsulation and high versatility in drug formulations.…”

Section: Introductionmentioning

confidence: 99%

Electrospun polymer fibers modified with FK506 for the long-term treatment of acute cardiac allograft rejection in a heart transplantation model

Deng

Jin

et al. 2023

Biomater. Sci.

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Continuous release of mefloquine featured in electrospun fiber membranes alleviates epidural fibrosis and aids in sensory neurological function after lumbar laminectomy

Cited by 3 publications

References 69 publications

Current Approaches, Significance and Prognostic Impact of Lumbar Ligament Flavum Preserving Surgeries

Current Approaches, Significance and Prognostic Impact of Lumbar Ligament Flavum Preserving Surgeries

Failed Back Surgery Syndrome: No Longer a Surgeon’s Defeat—A Narrative Review

Electrospun polymer fibers modified with FK506 for the long-term treatment of acute cardiac allograft rejection in a heart transplantation model

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