Continuous renal replacement therapy in sepsis-associated acute kidney injury: Effects on inflammatory mediators and coagulation function

Wu, Shi-Fang; Xu, Tao; Changxue, Wu; Xin, Lei; Tian, Xiaoli

doi:10.1016/j.asjsur.2021.02.004

Cited by 6 publications

(1 citation statement)

References 20 publications

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“…Rimmelé et al 2013 (23) explain that a hemoadsorption system capable of adsorbing cytokines and leukocytes was devised to assess the hypothesis that capturing leukocytes would change the profile of circulating cytokine and impact interactions between immunological cells in whole blood obtained from septic patients. Wu et al2021 (24) hoped that this study would shed light on the effects of CRRT in patients with sepsis-associated AKI. CRRT (group A) was given to 40 patients, while the others got standard treatment (group B).…”

Section: Related Workmentioning

confidence: 97%

Effects of Continuous Blood Purification without Heparin on Strem-1, NSE, and IL-10 Levels in Patients with Sepsis

Zeng¹,

Wu²,

Zhuo³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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One of the most common causes of mortality and disability across the world is sepsis, a condition marked by an abnormal immunological reaction in the body. The prognosis of patients with sepsis is much improved when they are diagnosed early and provided with proper therapy. Soluble triggering receptors expressed on myeloid cells (STREM-1), Interleukin-10 (IL-10), neuronal serum enolase (NSE), and so on are possible biomarkers for the diagnosis of sepsis based on the pathophysiology. Blood purification treatment to control the cytokine storm induced by sepsis was regarded to be promising. Recently, the treatment of sepsis is likely to shift toward a multimodal approach. Hence in this paper, we investigated the effect of a continuous blood purification technique (hemofiltration without heparin followed by hemoadsorption) on STREM-1, NSE, and IL-10 levels in patients suffering from sepsis. A sample of hundred patients suffering from sepsis was randomly allocated to one of the two groups (study and control groups). The control group got standard sepsis care, whereas the research group got continuous blood purification treatment. To compare the differences between the two groups, we used t-statistical analysis. Blood STREM-1, IL-10, and NSE concentrations of the study group were significantly lesser than that of the control group after therapy. As a result, continuous blood purification can significantly minimize the dysregulated immune response in patients with sepsis, promote immune function and improve the survival rate.

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Section: Related Workmentioning

confidence: 97%