Continuous Size Classification of Nanoparticles Utilizing Brownian Motion in Microchannel Size Exclusion Chromatography

Yamaguchi, Tetsuji; Okuyama, Kikuo

doi:10.1002/ppsc.200701097

Cited by 5 publications

(2 citation statements)

References 12 publications

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“…First we note that studies have shown the influence of the Saffman lift force on nanoparticles distribution. 25,26,36,37 However, their magnitudes are generally very small (~10 −14 N to 10 −16 N, as estimated for the present experiments) and there seems to be only a marginal change in the distribution of the particles due to the accounting of this force. However, for the sake of verification, we also conducted simulations with and without the Saffman lift consideration in the model; the comparison is shown in Fig.…”

Section: Discussionsupporting

confidence: 44%

Controlled splitting and focusing of a stream of nanoparticles in a converging–diverging microchannel

et al. 2014

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We demonstrate the potential of a converging-diverging microchannel to split a stream of nanoparticles towards the interfacial region of the dispersed and the carrier phases, introduced through the middle inlet and through the remaining two inlets respectively, while maintaining a low Reynolds number limit (<10) for the flow of both phases. In addition to the splitting of passive tracer particles, such as polystyrene beads as used herein, the present setup has the potential to be utilized for a controlled reaction and thereby the separation of products towards an intended location, as observed from the experimentation with silver-nanoparticles and hydrogen-peroxide solution. Moreover, the microscale dimension of the channel allows controlled deposition of the reaction product over the bottom surface of the channel, allowing the possibility of bottom-up fabrication of microscale features. We unveil the underlying hydrodynamics that lead to such behaviours through numerical simulations, which are consistent with the experimental observations. The phenomenological features are found to be guided by the splitting of the intrinsic streamlines conforming to the flow geometry under consideration.

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Section: Discussionsupporting

confidence: 44%

Controlled splitting and focusing of a stream of nanoparticles in a converging–diverging microchannel

et al. 2014

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“…In order to apply SEC to the separation of QDs and NPs, the strong adsorption of NPs to the surfaces due to the very high surface energy density of NPs should be inhibited. There are lots of studies done to separate NPs according to their size by using SEC, [8][9][10][11][12][13][14][15][16][17][18][19][20] however most systems used in these studies seem to be restricted in combination of the NPs and eluents. A technique should be developed which can inhibit adsorption of NPs onto the surface of the columns.…”

Section: Introductionmentioning

confidence: 99%

Size exclusion chromatography of quantum dots by utilizing nanoparticle repelling surface of concentrated polymer brush

2010

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We have found that the concentrated poly(methyl methacrylate) (PMMA) brush showed the very good nanoparticles (NPs) repellency in its good solvent, e.g. tetrahydrofuran (THF). Whereas the oil- and hydro-phobic (fluorinated), hydrophobic and hydrophilic surfaces adsorbed a lot of NPs. The repellency of NPs did not depend on the surface nature of the NPs. Preparing absorption free columns for size exclusion chromatography (SEC) may enable us to separate quantum dots (QDs) and NPs according to their size. By installing the concentrated PMMA brush into silica monolith columns, we tried to achieve SEC of QDs and NPs. The concentrated PMMA brush immobilized silica monolith columns were prepared by surface initiated atom transfer polymerization of MMA. As a result, we have succeeded in separating QDs according to their size. This SEC system may be advantageous because it can be used in good solvents of the brush regardless of the stability of the surface modifier layer on the NPs.

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Fractionation and characterization of nano- and microparticles in liquid media

et al. 2011

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Submicron and micron particles present in liquid environmental, biological, and technological samples differ in their dimensions, shape, mass, chemical composition, and charge. Their properties cannot be reliably studied unless the particles are fractionated. Synthetic particles applied as components of analytical systems may also need preliminary fractionation and investigation. The review is focused on the methods for fractionation and characterization of nanoparticles and microparticles in liquid media, the most representative examples of their application, and the trends in developing novel approaches to the separation and investigation of particles. Among the separation techniques, the main attention is devoted to membrane filtration, field-flow fractionation, chromatographic, and capillary electrokinetic methods. Microfluidic systems employing the above-mentioned and other separation principles and providing a basis for the fabrication of lab-on-chip devices are also examined. Laser light scattering methods and other physical techniques for the characterization of particles are considered. Special attention is given to "hyphenated" techniques which enable the separation and characterization of particles to be performed in online modes.

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Continuous Size Classification of Nanoparticles Utilizing Brownian Motion in Microchannel Size Exclusion Chromatography

Cited by 5 publications

References 12 publications

Controlled splitting and focusing of a stream of nanoparticles in a converging–diverging microchannel

Controlled splitting and focusing of a stream of nanoparticles in a converging–diverging microchannel

Size exclusion chromatography of quantum dots by utilizing nanoparticle repelling surface of concentrated polymer brush

Fractionation and characterization of nano- and microparticles in liquid media

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